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Objective
This study tested the hypothesis that treatment with the glucagon‐like peptide‐1/glucagon receptor agonist SAR425899 would lead to a smaller decrease in sleeping metabolic rate (SMR; kilocalories/day) than expected from the loss of lean and fat mass (metabolic adaptation).
Methods
This Phase 1b, double‐blind, randomized, placebo‐controlled study was conducted at two centers in inpatient...
Objective
This analysis aimed to measure the intraparticipant reliability—the intraclass correlation coefficient—of all the components of daily energy expenditure (EE) (24‐hour EE, sleep EE, resting EE, basal EE, and thermic effect of food) over a period of 3 consecutive days in 35 study participants.
Methods
The components of daily EE and substrate use (respiratory exchange ratio) were measured...
Bariatric surgery is effective in reducing body weight and obesity-related comorbidities. This study examined differences in the short-term effect of Roux en Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) on the hedonic rating of food. Predominantly black women with complicated obesity and a BMI>50g/m2 completed a validated food preference questionnaire before and 1–3 months following...
QRFP is expressed in central and peripheral regions important for nutrient intake and metabolism. Central administration of QRFP-26 and QRFP-43 induces a macronutrient specific increase in the intake of high fat diet in male and female rats. Recently, cell culture models have indicated that QRFP-26 and QRFP-43 are involved in glucose and fatty acid uptake in pancreatic islets and adipocytes. Since...
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