Search results for: Kylie J. Mansfield

Items from 1 to 13 out of 13 results

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The Australian health workforce: Disproportionate shortfalls in small rural towns

Colin H. Cortie, David Garne, Lyndal Parker‐Newlyn, Rowena G. Ivers, more

Australian Journal of Rural Health > 32 > 3 > 538 - 546

Introduction The distribution of health care workers differs greatly across Australia, which is likely to impact health delivery. Objective To examine demographic and workplace setting factors of doctors, nurses and midwives, and allied health professionals across Modified Monash Model (MMM) regions and identify factors associated with shortfalls in the health care workforce. Design Descriptive...

article

A comparison of rural and regional work locations and speciality choices between graduates from the University of Wollongong and all Australian medical schools using the Medical Schools Outcomes Database

Colin H. Cortie, David Garne, Lyndal Parker‐Newlyn, Rowena G. Ivers, more

Australian Journal of Rural Health > 32 > 1 > 152 - 161

Introduction The shortfall in medical workers in rural and remote Australia has led to health discrepancies in these regions. The University of Wollongong’s medical program was designed to encourage graduates to work in these regions to address this shortfall. Objective To compare rural and regional locations of work and choices of speciality between University of Wollongong's graduates and graduates...

article

An automated protocol for assessing career rurality outcomes of Australian health professionals using retrospective data

Colin H. Cortie, David Garne, Lyndal Parker‐Newlyn, Rowena G. Ivers, more

Australian Journal of Rural Health > 31 > 6 > 1252 - 1260

Introduction Addressing the imbalance of the health workforce between metropolitan and rural areas requires a clear understanding of trends in choices of work location of health care staff. Objective Here, we provide an automated and highly reproducible protocol to examine the location of health care workers over multiple years using medical graduates as a case study. Design Data linkage cohort...

article

Effect of antibiotics on urine leakage in women with refractory detrusor overactivity: A phase IIb randomized trial

Zhuoran Chen, Kate H. Moore, Kylie J. Mansfield, Samantha Ognenovska, more

Neurourology and Urodynamics > 40 > 1 > 158 - 167

Aim Because bacterial cystitis is common in women with refractory detrusor overactivity, the aim was to compare the efficacy of 6 weeks of rotating antibiotics versus placebo, in conjunction with an anticholinergic, in controlling the symptoms of urge incontinence. Methods In a multicenter phase IIb double‐blinded randomized placebo‐controlled trial, women with urodynamically proven refractory...

article

The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice

Nicholas J. Geraghty, Kylie J. Mansfield, Stephen J. Fuller, Debbie Watson, more

Purinergic Signalling > 2017 > 13 > 4 > 405-415

Psoriasis is a chronic inflammatory skin disorder, characterised by epidermal hyperplasia (acanthosis) and leukocyte infiltration of the skin. Current therapies are inadequate, highlighting the need for new therapeutic targets. The P2X7 receptor is implicated in the pathogenesis of psoriasis. This study investigated the role of P2X7 in imiquimod (IMQ)-induced psoriasis-like inflammation. Topically...

article

Correlation between cystometric volumes, ATP release, and pH in women with overactive bladder versus controls

Ying Cheng, Kylie J. Mansfield, Wendy Allen, Richard J. Millard, more

Neurourology and Urodynamics > 32 > 7 > 969 - 973

AimsIn the bladder, ATP is an important signaling molecule, which is released by bladder stretch and acid. We hypothesized that ATP might play a unique role in patients with OAB, characterized by low bladder volumes at first desire to void (FDV) and maximal cystometric capacity (MCC) and symptoms of frequency/urgency [mild bladder pain syndrome (BPS)]. Our aim was to investigate the correlation between...

article

Decreased Intravesical Adenosine Triphosphate in Patients with Refractory Detrusor Overactivity and Bacteriuria

Colin A. Walsh, Ying Cheng, Kylie J. Mansfield, Katrina Parkin, more

The Journal of Urology > 2013 > 189 > 4 > 1383-1387

Although several studies have examined the relationship between adenosine triphosphate release from the urothelium and bladder sensations including painful filling and urgency, the association between bacteriuria and urothelial adenosine triphosphate release has not been well studied. We evaluated women with refractory detrusor overactivity who were experiencing an acute exacerbation of detrusor overactivity...

article

Acid and stretch, but not capsaicin, are effective stimuli for ATP release in the porcine bladder mucosa: Are ASIC and TRPV1 receptors involved?

Prajni Sadananda, Felicity C.L. Kao, Lu Liu, Kylie J. Mansfield, more

European Journal of Pharmacology > 2012 > 683 > 1-3 > 252-259

Stretch-evoked ATP release from the bladder mucosa is a key event in signaling bladder fullness. Our aim was to examine whether acid and capsaicin can also release ATP and to determine the receptors involved, using agonists and antagonists at TRPV1 and acid-sensing ion channels (ASICs). Strips of porcine bladder mucosa were exposed to acid, capsaicin or stretch. Strip tension was monitored. Bath fluid...

article

Host–pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection

Thomas J. Hannan, Makrina Totsika, Kylie J. Mansfield, Kate H. Moore, more

FEMS Microbiology Reviews > 36 > 3 > 616 - 648

Bladder infections affect millions of people yearly, and recurrent symptomatic infections (cystitis) are very common. The rapid increase in infections caused by multidrug‐resistant uropathogens threatens to make recurrent cystitis an increasingly troubling public health concern. Uropathogenic Escherichia coli (UPEC) cause the vast majority of bladder infections. Upon entry into the lower urinary tract,...

article

Does Adenosine Triphosphate Released Into Voided Urodynamic Fluid Contribute to Urgency Signaling in Women With Bladder Dysfunction?

Ying Cheng, Kylie J. Mansfield, Wendy Allen, Colin A. Walsh, more

The Journal of Urology > 2010 > 183 > 3 > 1082-1086

Adenosine triphosphate released from urothelium during stretch stimulates afferent nerves and conveys information on bladder fullness. We measured adenosine triphosphate released during cystometric bladder filling in women with idiopathic detrusor overactivity and stress incontinence (controls), and assessed whether the level of released adenosine triphosphate is related to cystometric parameters...

article

ATP RELEASE IN RESPONSE TO ACID AND CAPSAICIN PROVIDES EVIDENCE FOR SENSORY ROLES OF VANILLOID AND ASIC RECEPTOR SYSTEMS IN THE RAT BLADDER MUCOSA

Prajni Sadananda, Kylie J Mansfield, Elizabeth Burcher

The Journal of Urology > 2009 > 181 > 4 Supplement > 147

article

Age-related changes of P2X1 receptor mRNA in the bladder detrusor from men with and without bladder outlet obstruction

Wendy Chen-Nee Chua, Lu Liu, Kylie J. Mansfield, Kenneth J. Vaux, more

Experimental Gerontology > 2007 > 42 > 7 > 686-692

The urinary bladder purinergic system is reported to change with age and with bladder dysfunction. Here, we examined the expression of purinergic P2X ₁ receptors in detrusor and mucosa (urothelium+lamina propria) from male control bladder and investigated age-related P2X ₁ receptor mRNA expression in control and obstructed detrusor. Biopsy specimens were obtained at cystoscopy from...

article

Muscarinic receptor subtypes in the human colon: lack of evidence for atypical subtypes

Kylie J. Mansfield, Frederick J. Mitchelson, Kate H. Moore, Elizabeth Burcher

European Journal of Pharmacology > 2003 > 482 > 1-3 > 101-109

Characteristics of muscarinic receptors were investigated in circular muscle from normal human colon. In saturation studies (n=18), binding of [ ³ H]quinuclidinyl benzylate (QNB) was of high affinity (K _d 87.3 pM) and capacity (B _m _a _x 362+/-27 fmol/mg protein), with no differences between ascending and sigmoid colon. Kinetic studies gave a K _d of 55 pM. Methoctramine...

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Keywords

ADENOSINE TRIPHOSPHATE (2)
URINARY BLADDER (2)
URODYNAMICS (2)
WORKFORCE PLANNING (2)
[ 3 H]QUINUCLIDINYL BENZYLATE (1)
ACID (1)
AGING (1)
ALKYLATING AGENT (1)
ANTIBIOTIC RESISTANCE (1)
ANTIBIOTIC THERAPY (1)
ASIC RECEPTOR (ACID-SENSING ION CHANNELS) (1)
ATP (ADENOSINE TRIPHOSPHATE) (1)
ATP RELEASE (1)
BACTERIURIA (1)
BLADDER (1)
BLADDER OUTLET OBSTRUCTION (1)
BLADDER PAIN SYNDROME (1)
CAPSAICIN (1)
CIRCULAR MUSCLE (1)
COLON (1)
CURRICULUM DESIGN AND ASSESSMENT (1)
CYSTITIS (1)
DETRUSOR (1)
EXTRACELLULAR ATP (1)
GENERAL PRACTICE (1)
HUMAN (1)
IMIQUIMOD (1)
INTRACELLULAR BACTERIAL COMMUNITIES (1)
LONGITUDINAL TRACKING (1)
MEDICAL EDUCATION (1)
MEDICAL SCHOOL OUTCOMES DATABASE (1)
MEDICAL STUDENTS (1)
MODIFIED MONASH (1)
MSOD (1)
MUSCARINIC RECEPTOR (1)
OVERACTIVE (1)
OVERACTIVE BLADDER (1)
P2X1 RECEPTORS (1)
P2X7 RECEPTOR (1)
PSORIASIS (1)
QUANTITATIVE COMPETITIVE-RT-PCR (1)
RADIOLIGAND BINDING (1)
RECURRENT URINARY TRACT INFECTIONS (1)
REFRACTORY DETRUSOR OVERACTIVITY (1)
REMOTE HEALTH (1)
RURAL HEALTH (1)
RURAL WORKFORCE DEVELOPMENT (1)
SKIN IMMUNE SYSTEM (1)
STRESS (1)
TRPV1 (TRANSIENT RECEPTOR POTENTIAL VANILLOID RECEPTOR 1) (1)
TYPE 1 PILI (1)
UPEC (1)
URGE (1)
URGE INCONTINENCE (1)
URGENCY (1)
URINARY BLADDER, OVERACTIVE (1)
URINARY INCONTINENCE (1)
URINARY TRACT INFECTION (1)
URINE PH (1)
UROTHELIUM (1)
WORKFORCE STUDIES (1)
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Elsevier (6)
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Springer (1)

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