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A recently developed model for pretreatment and acid or alkaline hydrolyses of lignocellulosic biomasses, including blue agave bagasse (BAB), in twin‐screw corotating extruders is extended to the case where enzymes are incorporated into the formulation. The model describes the deconstruction and degradation of BAB, as well as the production of simple sugars at the end of the extrusion process. Experiments...