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Flagella‐mediated swimming and swarming motility in Salmonella enterica serovar Typhimurium is intercalated with the cyclic di‐guanylate monophosphate (c‐di‐GMP) signalling network. In this study, we identified the GGDEF domain proteins STM2672, STM4551 and STM1987 as key di‐guanylate cyclases involved in regulation of motility in a ΔyhjH phosphodiesterase gene deletion mutant with elevated c‐di‐GMP...
The ubiquitous second messenger c‐di‐GMP regulates the switching of bacterial lifestyles from motility to sessility and acute to chronic virulence to adjust bacterial fitness to altered environmental conditions. Conventionally, EAL proteins being c‐di‐GMP phosphodiesterases promote motility and acute virulence phenotypes such as invasion into epithelial cells and inhibit biofilm formation. We report...
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