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Many bacterial pathogens have evolved distinct ways of disarming the inflammatory response and prolonging infection. Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) interfere with the immune response by injecting virulence effector proteins into the host cell that shut down innate immune signalling pathways. We have identified effector proteins that prevent the activation of...
Legionellosis or Legionnaires’ disease is an emerging and often‐fatal form of pneumonia that is most severe in elderly and immunocompromised people, an ever‐increasing risk group for infection. In recent years, the genomics of Legionella spp. has significantly increased our knowledge of the pathogenesis of this disease by providing new insights into the evolution and genetic and physiological basis...
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