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We herein developed a self‐assembling peptide with the ability to form a gel in water at pH ∼7 (SPG‐178 (a self‐assembling peptide gel with the amino acid sequence #178; [CH3CO]‐RLDLRLALRLDLR‐[NH2]; R = arginine, L = leucine, D = aspartic acid, and A = alanine). Leucine residues were employed to increase the hydrophobic interaction of SPG‐178 in water, which was one of the important driving forces...
A unique subset of B cells expressing interleukin‐10 (IL‐10) and transforming growth factor‐β (TGF‐β) plays an essential role in preventing inflammation and autoimmunity. We investigated the presence of this cell subset in intestines and its role in the pathogenesis of ileitis using SAMP1/Yit and age‐matched control AKR/J mice. Mononuclear cells were isolated from mesenteric lymph nodes (MLNs) and...
The lactogenic hormone prolactin (PRL) regulates milk protein gene expression in mammary glands. To maintain homeostatic balance in the body, milk fat globule epidermal growth factor 8 (MFG-E8) is vital for phagocytic clearance of apoptotic cells. We investigated the effects of PRL on MFG-E8 expression in macrophages by evaluating its promoter function. Macrophages were stimulated with PRL, and the...
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