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This study examined regional changes of 5-HT 2A and 2C receptor mRNA expression in the rat brain after chronic administration of clozapine (1.5mg/kg/day) and haloperidol (2.0mg/kg/day) for 36 days. 5-HT 2A and 2C receptor mRNA expression and distributions were detected by in situ hybridization after rats were sacrificed either 2 or 48h after the last drug administration to examine...
This study examined regional changes in rat brain mRNA levels encoding 5-HT 2A and 5-HT 2C receptors following chronic olanzapine treatment. The immediate effect (2h after the last treatment) was a down-regulation of 5-HT 2A receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48h later. 5-HT 2C ...
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