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Background & Aims
Experimental evidence indicates that systemic inflammation (SI) promotes liver fibrogenesis. This study investigated the potential link between SI and fibrogenesis in patients with advanced chronic liver disease (ACLD).
Methods
Serum biomarkers of SI (CRP, IL‐6, procalcitonin [PCT]) and extracellular matrix (ECM) turnover (i.e., fibrogenesis/fibrolysis) were analysed in 215...
Background and Aims
Liver fibrosis is the static and main (70%‐80%) component of portal hypertension (PH). We investigated dynamic components of PH by a three‐dimensional analysis based on correlation of hepatic collagen proportionate area (CPA) with portal pressure (PP) in animals or HVPG in patients.
Approach and Results
Different animal models (bile duct ligation: n = 31, carbon tetrachloride:...
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