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An alumina (Al2O3)–steroid–ethanol model is used for forced degradation testing of corticosteroids to predict chemical stability and degradation products in pressurized metered‐dose inhaler (pMDI) solution formulations. The model involves an ethanolic solution of a test steroid with Al2O3, stressed at elevated temperatures to mimic the chemical interaction of drug, excipient, and packaging (an aluminum...
Perfluorooctanesulfonyl fluoride (POSF, C 8 F 17 SO 2 F) related-materials have been used as surfactants, paper and packaging treatments, and surface (e.g., carpet, textile, upholstery) protectants. A metabolite, perfluorooctanesulfonate (PFOS, C 8 F 17 SO 3- ), has been identified in the serum and liver of non-occupationally exposed humans...
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