Search results for: Robert Vassallo

Items from 1 to 20 out of 43 results

article

Proximal Scar Progression in Idiopathic Subglottic Stenosis After Wedge Excision: Does it Happen?

Katherine Z. Xie, Andrew Jay Bowen, Bradley A. Richards, Aisha Aden, more

Objective To compare the incidence of glottic stenosis in idiopathic subglottic stenosis (iSGS) patients with no prior surgical intervention to those with a history of endoscopic dilation and characterize the incidence of glottic involvement, changes in scar length, and progression of scar toward glottis following laser wedge excision (LWE). Methods A retrospective review of iSGS patients who underwent...

article

Incidence, Risk Factors, and Mortality of Clinical and Subclinical Rheumatoid Arthritis–Associated Interstitial Lung Disease: A Population‐Based Cohort

Bilal F. Samhouri, Robert Vassallo, Sara J. Achenbach, Vanessa L. Kronzer, more

Arthritis Care & Research > 74 > 12 > 2042 - 2049

Objective To identify the incidence, risk factors, and outcomes of rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) and to assess time trends in the incidence and mortality in RA‐ILD. Methods We included adult residents of Olmsted County, Minnesota with incident RA between 1999 and 2014. Subjects were followed until death, emigration, or April 30, 2019. ILD was defined as the...

article

Classical and non‐classical phenotypes of Erdheim–Chester disease: Correlating clinical, radiographic and genotypic findings

Antonious Z. Hazim, Aldo A. Acosta‐Medina, Jason R. Young, Gordon J. Ruan, more

British Journal of Haematology > 199 > 3 > 454 - 457

article

Mimics of Erdheim–Chester disease

Jithma P. Abeykoon, Aishwarya Ravindran, Karen L. Rech, Jason R. Young, more

British Journal of Haematology > 196 > 4 > 984 - 994

Erdheim–Chester disease (ECD) is a rare histiocytic neoplasm with frequent multiorgan involvement. An accurate diagnosis of ECD requires the correlation of clinical features, histopathologic and radiologic findings. We describe a case series of patients with a referral diagnosis of ECD, whereby the diagnosis was changed to non‐histiocytic diseases after comprehensive review at a tertiary care center...

article

Sustained, complete response to pexidartinib in a patient with CSF1R‐mutated Erdheim–Chester disease

Jithma P. Abeykoon, Terra L. Lasho, Surendra Dasari, Karen L. Rech, more

American Journal of Hematology > 97 > 3 > 293 - 302

Erdheim–Chester disease (ECD) is a histiocytic neoplasm that predominantly harbors mitogen‐activated protein kinase (MAPK) pathway variants. MAPK inhibitors typically are effective treatments, but mutations outside the MAPK pathway, such as CSF1R variants, may cause refractory ECD. We describe a patient with a novel somatic mutation in CSF1R (CSF1R^{R549_E554delinsQ}) that resulted in refractory ECD...

article

Langerhans cell histiocytosis with lung involvement in isolation and multisystem disease: Staging, natural history, and comparative survival

Antonious Z. Hazim, Gordon J. Ruan, Marie Hu, Aishwarya Ravindran, more

American Journal of Hematology > 96 > 12 > 1604 - 1610

Langerhans cell histiocytosis (LCH) is a histiocytic neoplasm that can involve the lungs as single system (LCH‐SSL) or multisystem disease (LCH‐MSL). The role of full‐body radiographic staging to determine whether patients have LCH‐SSL or LCH‐MSL is unclear. Long‐term outcomes of LCH‐SSL versus LCH‐MSL and multisystem without lung involvement (LCH‐MSNL) are unknown. A retrospective study of adult...

article

Single‐agent cladribine as an effective front‐line therapy for adults with Langerhans cell histiocytosis

Gaurav Goyal, Jithma P. Abeykoon, Marie Hu, Jason R. Young, more

American Journal of Hematology > 96 > 5 > E146 - E150

article

Management and outcomes of pneumothorax in adult patients with Langerhans cell Histiocytosis

Pierre Le Guen, Sylvie Chevret, Emmanuelle Bugnet, Constance Margerie-Mellon, more

Orphanet Journal of Rare Diseases > 2019 > 14 > 1 > 1-9

Background Pneumothorax may recur during pulmonary Langerhans cell histiocytosis (PLCH) patients’ follow-up and its management is not standardised. The factors associated with pneumothorax recurrence are unknown. Methods In this retrospective study, PLCH patients who experienced a pneumothorax and were followed for at least 6 months after the first episode were eligible. The objectives were to describe...

article

Investigating Asthma, Allergic Disease, Passive Smoke Exposure, and Risk of Rheumatoid Arthritis

Vanessa L. Kronzer, Cynthia S. Crowson, Jeffrey A. Sparks, Robert Vassallo, more

Arthritis & Rheumatology > 71 > 8 > 1217 - 1224

Objective Rheumatoid arthritis (RA) is postulated to originate at mucosal surfaces, particularly the airway mucosa. To investigate this hypothesis, we determined the association between RA and asthma, passive smoke exposure, and age at start of smoking. Methods For this case–control study, we identified 1,023 cases of RA (175 incident) within a single‐center biobank population, using a rules‐based...

article

Efficacy of biological agents in the treatment of Erdheim‐Chester disease

Gaurav Goyal, Mithun V. Shah, Timothy G. Call, Mark R. Litzow, more

British Journal of Haematology > 183 > 3 > 520 - 524

article

Micro-anatomical structure of the first spine of the dorsal fin of Atlantic bluefin tuna, Thunnus thynnus (Osteichthyes: Scombridae)

Nicoletta Santamaria, Giambattista Bello, Letizia Passantino, Mariasevera Di Comite, more

Annals of Anatomy - Anatomischer Anzeiger > 2018 > 219 > C > 1-7

The first spine of the first dorsal fin (FS) of the Atlantic bluefin tuna (ABFT), Thunnus thynnus, is customarily used in age determination research because its transverse sections display well-defined growth marks. In this paper the FS structure was studied to explain its known dramatic age- and season-related morphological modifications, which are evidently caused by bone remodeling. Cross sections...

article

Quantitative assessment of lung stiffness in patients with interstitial lung disease using MR elastography

John P. Marinelli, David L. Levin, Robert Vassallo, Rickey E. Carter, more

Journal of Magnetic Resonance Imaging > 46 > 2 > spcone - spcone

Purpose To investigate the use of magnetic resonance elastography (MRE) in the quantitative assessment of pulmonary fibrosis by comparing quantitative shear stiffness measurements of lung parenchyma in patients diagnosed with fibrotic interstitial lung disease (ILD) and healthy controls. Materials and Methods A 1.5T spin‐echo, echo planar imaging MRE (SE‐EPI MRE) pulse sequence was utilized to...

article

Quantitative assessment of lung stiffness in patients with interstitial lung disease using MR elastography

John P. Marinelli, David L. Levin, Robert Vassallo, Rickey E. Carter, more

Journal of Magnetic Resonance Imaging > 46 > 2 > 365 - 374

article

A phase IIa study of afuresertib, an oral pan‐AKT inhibitor, in patients with Langerhans cell histiocytosis

Robert J. Arceci, Carl E. Allen, Ira J. Dunkel, Eric Jacobsen, more

Pediatric Blood & Cancer > 64 > 5 > n/a - n/a

Background Langerhans cell histiocytosis (LCH) is a clonal neoplasm characterized by widely varied clinical presentations, including multisystem involvement and systemic inflammatory symptoms. The AKT pathway is relevant to survival and proliferation of dendritic cells, and is also often upregulated in hematopoietic malignancies. A clinical response in an adult patient with LCH participating in the...

article

Functional Effects of Cigarette Smoke‐Induced Changes in Airway Smooth Muscle Mitochondrial Morphology

Bharathi Aravamudan, Michael Thompson, Gary C. Sieck, Robert Vassallo, more

Journal of Cellular Physiology > 232 > 5 > 1053 - 1068

Long‐term exposure to cigarette smoke (CS) triggers airway hyperreactivity and remodeling, effects that involve airway smooth muscle (ASM). We previously showed that CS destabilizes the networked morphology of mitochondria in human ASM by regulating the expression of mitochondrial fission and fusion proteins via multiple signaling mechanisms. Emerging data link regulation of mitochondrial morphology...

article

Asthma and orbital immunoglobulin G4–related disease

Misbah Baqir, James A. Garrity, Robert Vassallo, Thomas E. Witzig, more

Annals of Allergy, Asthma & Immunology > 2016 > 116 > 4 > 313-316

An association has been suggested between asthma and orbital immunoglobulin G4–related disease (IgG4-RD).To explore this association, including asthma characteristics and risk factors.A retrospective, computer-assisted search identified patients with orbital IgG4-RD seen at Mayo Clinic in Rochester, Minnesota from 1997 to 2014. Asthma prevalence and its related clinical and radiologic characteristics...

chapter

Pulmonary Langerhans’ Cell Histiocytosis – Advances in the Understanding of a True Dendritic Cell Lung Disease

Robert Vassallo

Respiratory Medicine > Molecular Basis of Pulmonary Disease > 369-388

Pulmonary Langerhans’ cell histiocytosis (PLCH) is a rare lung disease that generally, but not invariably, occurs in cigarette smokers. The pathologic hallmark of PLCH is expansion of Langerhans and other inflammatory cells in a bronchiolocentric fashion. The precise mechanisms by which smoking induces PLCH in susceptible individuals are not known, but likely involve a combination of molecular events...

article

Innovative intervention to improve fellows’ research training

Kannan Ramar, Robert Vassallo, Darlene R Nelson, Jay Ryu

Medical Education > 49 > 11 > 1159 - 1159

article

Extracts from presumed “reduced harm” cigarettes induce equivalent or greater toxicity in antigen-presenting cells

Robert Vassallo, Lei Wang, Yoshimi Hirano, Paula Walters, more

Toxicology > 2015 > 335 > Complete > 46-54

The tobacco industry has promoted certain cigarette products with claims that their use may be less harmful to the smoker as they purportedly deliver lower amounts of toxic chemicals compared to conventional cigarettes. This study was designed to compare the relative antigen presenting cellular toxicity of Eclipse, a presumed reduced exposure product (PREP) cigarette, when compared with the reference...

article

Dramatic and sustained responsiveness of pulmonary Langerhans cell histiocytosis-associated pulmonary hypertension to vasodilator therapy

Adam May, Garvan Kane, Eunhee Yi, Robert Frantz, more

Respiratory Medicine Case Reports > 2015 > 14 > Complete > 13-15

Pulmonary Langerhans cell histiocytosis (PLCH) is an uncommon diffuse lung disease characterized by the abnormal accumulation of Langerhans' cells around small airways and other distal lung compartments. Although pulmonary hypertension (PH) is a frequent complication of PLCH, the role of advanced PH therapies for PLCH-related PH is not well-established. We describe a PLCH patient with severe, disease-related...

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INFONA - science communication portal

Search results for: Robert Vassallo

Proximal Scar Progression in Idiopathic Subglottic Stenosis After Wedge Excision: Does it Happen?

Incidence, Risk Factors, and Mortality of Clinical and Subclinical Rheumatoid Arthritis–Associated Interstitial Lung Disease: A Population‐Based Cohort

Classical and non‐classical phenotypes of Erdheim–Chester disease: Correlating clinical, radiographic and genotypic findings

Mimics of Erdheim–Chester disease

Sustained, complete response to pexidartinib in a patient with CSF1R‐mutated Erdheim–Chester disease

Langerhans cell histiocytosis with lung involvement in isolation and multisystem disease: Staging, natural history, and comparative survival

Single‐agent cladribine as an effective front‐line therapy for adults with Langerhans cell histiocytosis

Management and outcomes of pneumothorax in adult patients with Langerhans cell Histiocytosis

Investigating Asthma, Allergic Disease, Passive Smoke Exposure, and Risk of Rheumatoid Arthritis

Efficacy of biological agents in the treatment of Erdheim‐Chester disease

Micro-anatomical structure of the first spine of the dorsal fin of Atlantic bluefin tuna, Thunnus thynnus (Osteichthyes: Scombridae)

Quantitative assessment of lung stiffness in patients with interstitial lung disease using MR elastography

Quantitative assessment of lung stiffness in patients with interstitial lung disease using MR elastography

A phase IIa study of afuresertib, an oral pan‐AKT inhibitor, in patients with Langerhans cell histiocytosis

Functional Effects of Cigarette Smoke‐Induced Changes in Airway Smooth Muscle Mitochondrial Morphology

Asthma and orbital immunoglobulin G4–related disease

Pulmonary Langerhans’ Cell Histiocytosis – Advances in the Understanding of a True Dendritic Cell Lung Disease

Innovative intervention to improve fellows’ research training

Extracts from presumed “reduced harm” cigarettes induce equivalent or greater toxicity in antigen-presenting cells

Dramatic and sustained responsiveness of pulmonary Langerhans cell histiocytosis-associated pulmonary hypertension to vasodilator therapy

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