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Thiamidol® was the most potent inhibitor of human tyrosinase out of 50 000 screened substances. In vivo, it was well tolerated and improved melasma significantly. This was the first 24‐week, randomized, double‐blind, vehicle‐controlled, cosmetic clinical study to assess the efficacy and tolerability of thiamidol in moderate‐to‐severe melasma of phototype III–V subjects with subsequent regression phase...