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The anticancer agent, cisplatin (CIS), is associated with hepatotoxic effects related to activation of oxidative stress and inflammation pathways. CIS‐induced oxidative DNA damage reduces sirtuin 1 (SIRT1) activity, which in turn, modulates the activity of peroxisome proliferator‐activated receptor‐gamma coactivator 1‐alpha (PGC‐1α). Moreover, microRNA‐34a (miRNA‐34a) was shown to hinder both SIRT1...