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Distinction between normal skin and pathology can be a diagnostic challenge. This systematic review summarizes how various contrast agents, either topically delivered or injected into the skin, affect distinction between skin disease and normal skin when imaged by optical coherence tomography (OCT) and confocal microscopy (CM). A systematic review of in vivo OCT and CM studies using exogenous contrast...
Optical coherence tomography (OCT) is an established imaging technology for in vivo skin investigation. Topical application of gold nanoshells (GNS) provides contrast enhancement in OCT by generating a strong hyperreflective signal from hair follicles and sweat glands, which are the natural skin openings. This study explores the utility of 150 nm diameter GNS as contrast agent for OCT imaging. GNS...
Optical coherence tomography (OCT) is a non-invasive imaging technique with many applications and widespread use in ophthalmology [1]. The axial resolution in OCT is inversely proportional to the bandwidth of the optical source used, but the improved axial resolution comes at the price of more significant effects of dispersion stemming from the imaging system and the imaged medium. In recent years,...
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