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α7‐Nicotinic acetylcholine receptor (α7‐nAChR) is the key effector molecule of the cholinergic anti‐inflammatory pathway. Evolution has evolved a uniquely human α7‐nAChR encoded by CHRFAM7A. It has been demonstrated that CHRFAM7A dominant negatively regulates the functions of α7‐nAChR. However, its role in inflammation remains to be fully characterized. CHRFAM7A transgenic (Tg) mice were phenotypically...
Migrasomes comprise a recently identified unique type of extracellular vesicle (EV) containing varying numbers of small vesicles. However, the final fate of these small vesicles is still unclear. Here, we report the discovery of EV‐like migrasome‐derived nanoparticles (MDNPs) that are produced by migrasomes releasing internal vesicles via self‐rupture and through a process similar to cell plasma membrane...
Our studies were conducted to investigate the clinical and functional significance of tumor‐associated macrophages (TAMs) in cervical tumor lymphatic metastasis. We found that the increase in macrophages in tumor stroma is significantly associated with lymphatic metastasis (p=0.017), through performing immunohistochemical staining in 111 cervical samples (55 invasive squamous carcinomas of uterine...
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