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A major pathological feature of Parkinson's disease (PD) is the aberrant accumulation of misfolded assemblies of alpha‐synuclein (α‐Syn). Protein clearance appears as a regulator of the ‘α‐Syn burden’ underlying PD pathogenesis. The picture emerging is that a combination of pathways with complementary roles, including the Proteasome System and the Autophagy–Lysosome Pathway, contributes to the intracellular...
Synucleinopathies are neurodegenerative diseases characterized by the accumulation of either neuronal/axonal or glial insoluble proteinaceous aggregates mainly composed of α‐synuclein (α‐syn). Among them, the most common disorders are Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and some forms of familial parkinsonism. Both α‐syn fibrils and oligomers have been found to...
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