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GATA factors play central roles in the programming of blood and cardiac cells during embryonic development. Using the experimentally accessible Xenopus and zebrafish models, we report observations regarding the roles of GATA‐2 in the development of blood stem cells and GATA‐4, ‐5, and ‐6 in cardiac development. We show that blood stem cells develop from the dorsal lateral plate mesoderm and GATA‐2...