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Cytotoxic T‐lymphocyte‐associated antigen 4 (CTLA‐4) molecule is expressed on T‐lymphocyte membrane and negatively influences the antigen‐presenting process. Reduced expression of CTLA‐4 due to gene polymorphisms is associated with increased risk of autoimmune disorders, whose physiopathology is similar to that of post‐transfusion red blood cell (RBC) alloimmunization. Our goal was to evaluate if...
Background
High‐throughput molecular assays are essential tools for the search of rare blood donors.
Aims and methods
To evaluate a fully automated workflow designed for genotyping blood donors’ red blood cell (RBC) and platelets (PTL) antigens using the OpenArray Real‐time PCR system.
Results
5487 blood donors were genotyped using the proposed strategy in two steps: (1) nucleic acid purification...
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