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TG02 is a novel cyclin‐dependent kinase (CDK) inhibitor and thought to act mainly via CDK‐9 inhibition‐dependent depletion of short‐lived oncoproteins such as MCL‐1 or c‐MYC. We studied the activity of TG02 in 9 human long‐term glioma cell lines (LTC) and 5 glioma‐initiating cell lines (GIC) using various cell death assays in vitro and in the LN‐229 LTC and ZH‐161 GIC models in vivo. TG02 exhibits...