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The PI3K‐Akt pathway is one of the most commonly dysregulated cancer‐associated signaling pathways. Here we report an oncogenic function for the miR‐181 family in luminal breast cancer cells that involves Akt hyperactivation. We show that miR‐181a and miR‐181d posttranscriptionally suppress the expression of PHLPP2 and INPP4B phosphatases, resulting in elevated growth factor‐induced Akt phosphorylation...