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The role of STAT2 in mediating the antigrowth effects of type I interferon (IFN) is well‐documented in vitro. Yet evidence of IFN‐activated STAT2 as having tumor suppressor function in vivo and participation in antitumor immunity is lacking. Here we show in a syngeneic tumor transplantation model that STAT2 reduces tumor growth. Stat2−/− mice formed larger tumors compared to wild type (WT) mice. IFN‐β...