Search results for: Shosuke Ito

Items from 1 to 20 out of 97 results

article

2‐Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity

Peggy Sextius, Emilie Warrick, Amélie Prévot‐Guéguiniat, Guillaume Lereaux, more

Pigment Cell & Melanoma Research > 37 > 4 > 462 - 479

Research on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High‐throughput screening...

article

Genetic insights into Tietz albinism‐deafness syndrome: A new dominant‐negative mutation in MITF

Kohei Yamamoto, Ken Okamura, Kazumasa Wakamatsu, Shosuke Ito, more

Pigment Cell & Melanoma Research > 37 > 4 > 430 - 437

Tietz albinism‐deafness syndrome (TADS) is a rare and severe manifestation of Waardenburg syndrome that is primarily linked to mutations in MITF. In this report, we present a case of TADS resulting from a novel c.637G>C mutation in MITF (p.Glu213Gln; GenBank Accession number: NM_000248). A 3‐year‐old girl presented with congenital generalized hypopigmentation of the hair, skin, and irides along...

article

Cytoglobin functions as a redox regulator of melanogenesis in normal epidermal melanocytes

Yo Tanaka, Misako Sato‐Matsubara, Daisuke Tsuruta, Hiroshi Tanaka, more

Pigment Cell & Melanoma Research > 37 > 2 > 276 - 285

Epidermal melanocytes are continuously exposed to sunlight‐induced reactive oxygen species (ROS) and oxidative stress generated during the synthesis of melanin. Therefore, they have developed mechanisms that maintain normal redox homeostasis. Cytoglobin (CYGB), a ubiquitously expressed intracellular iron hexacoordinated globin, exhibits antioxidant activity and regulates the redox state of mammalian...

article

Cyclic oscillations in melanization within Hystrix porcupine quills

Thomas P. Dooley, Sydney Anderson, Shosuke Ito, Kazumasa Wakamatsu

Pigment Cell & Melanoma Research > 36 > 3-4 > 321 - 324

article

Impact of a SLC24A5 variant on the retinal pigment epithelium of a Japanese patient with oculocutaneous albinism type 6

Toru Saito, Ken Okamura, Rika Kosaki, Kazumasa Wakamatsu, more

Pigment Cell & Melanoma Research > 35 > 2 > 212 - 219

Oculocutaneous albinism (OCA) 6 is a non‐syndromic type of OCA that has distinct ocular symptoms and variable cutaneous hypopigmentation. The causative gene of OCA6 is SLC24A5, which encodes NCKX5, a K⁺‐dependent Na⁺/Ca²⁺ exchanger 5. NCKX5 is involved in the maturation of melanosomes, but its function is still unclear. In this study, we characterized a Japanese patient with OCA6. Genetic analysis...

article

Photobleached Oxidative Degradation of Melanins: Chemical Characterization of Melanins Present in Alpaca Fiber

Kazumasa Wakamatsu, Kylie Munyard, Carolyn Oddie, Shosuke Ito

Photochemistry and Photobiology > 97 > 6 > 1493 - 1497

In order to characterize the phenotype and to examine the effects of sun exposure on the color and structure of eumelanin (EM) and pheomelanin (PM) in alpaca fibers, we applied Soluene‐350 solubilization, alkaline hydrogen peroxide oxidation (AHPO) and hydroiodic acid (HI) hydrolysis to the base and tip fibers of 20 true‐black (TB) and 20 warm‐black (WB) alpacas. We analyzed absorbances at 500 nm...

article

Special issue: “Biology of skin pigmentation and pigmentary diseases”

Shosuke Ito, Zalfa Abdel‐Malek, Mauro Picardo

Pigment Cell & Melanoma Research > 34 > 4 > 705 - 706

article

Chemical and biochemical control of skin pigmentation with special emphasis on mixed melanogenesis

Kazumasa Wakamatsu, Jonathan H. Zippin, Shosuke Ito

Pigment Cell & Melanoma Research > 34 > 4 > 730 - 747

Melanins are widely distributed in animals and plants; in vertebrates, most melanins are present on the body surface. The diversity of pigmentation in vertebrates is mainly attributed to the quantity and ratio of eumelanin and pheomelanin synthesis. Most natural melanin pigments in animals consist of both eumelanin and pheomelanin in varying ratios, and thus, their combined synthesis is called “mixed...

article

Rhododendrol‐induced leukoderma update II: Pathophysiology, mechanisms, risk evaluation, and possible mechanism‐based treatments in comparison with vitiligo

Shintaro Inoue, Ichiro Katayama, Tamio Suzuki, Atsushi Tanemura, more

The Journal of Dermatology > 48 > 7 > 969 - 978

A small proportion of individuals utilizing cosmetics containing rhododendrol developed leukoderma with various pathological conditions, in some cases indistinguishable from vitiligo. In this review, we investigate and evaluate the major considerations for developing rhododendrol‐induced leukoderma based on data from original or review articles published in the literature to provide a wide range of...

article

Rhododendrol‐induced leukoderma update I: Clinical findings and treatment

Kayoko Matsunaga, Kayoko Suzuki, Akiko Ito, Atsushi Tanemura, more

The Journal of Dermatology > 48 > 7 > 961 - 968

Individuals who used skin‐whitening cosmetics (quasi‐drugs) containing 2% rhododendrol‐containing agents, developed leukoderma at a higher frequency than those who have used other skin‐whitening cosmetics. The Rhododenol Research Team (RD‐Team) was formed and commissioned by Kanebo Cosmetics Inc. to conduct research in treatments of rhododendrol‐induced leukoderma (RDL), to evaluate effective treatment...

article

Application of mid‐infrared free‐electron laser for structural analysis of biological materials

Takayasu Kawasaki, Heishun Zen, Kento Ozaki, Hironari Yamada, more

Journal of Synchrotron Radiation > 28 > 1 > 28 - 35

A mid‐infrared free‐electron laser (MIR‐FEL) is a synchrotron‐radiation‐based femto‐ to pico‐second pulse laser. It has unique characteristics such as variable wavelengths in the infrared region and an intense pulse energy. So far, MIR‐FELs have been utilized to perform multi‐photon absorption reactions against various gas molecules and protein aggregates in physical chemistry and biomedical fields...

article

Establishment of a mouse model for post‐inflammatory hyperpigmentation

Shoko Nakano, Yuko Abe, Kimiko Nakajima, Shigetoshi Sano, more

Pigment Cell & Melanoma Research > 34 > 1 > 101 - 110

Post‐inflammatory hyperpigmentation (PIH) is a common cutaneous condition that can cause a disfigured appearance. However, the pathophysiology of PIH remains poorly understood, at least in part, because an appropriate animal model for research has not been established. In order to analyze the pathomechanism of PIH, we successfully induced PIH in a hairless version of transgenic mice (hk14‐SCF Tg/HRM)...

article

Kojic acid alters pheomelanin content in human induced pluripotent stem cell‐derived melanocytes

Chie Miyabe, Yupeng Dong, Kazumasa Wakamatsu, Shosuke Ito, more

The Journal of Dermatology > 47 > 4 > 435 - 436

article

Taphonomic experiments resolve controls on the preservation of melanosomes and keratinous tissues in feathers

Tiffany S. Slater, Maria E. McNamara, Patrick J. Orr, Tara B. Foley, more

Palaeontology > 63 > 1 > 103 - 115

Fossils are a key source of data on the evolution of feather structure and function through deep time, but their ability to resolve macroevolutionary questions is compromised by an incomplete understanding of their taphonomy. Critically, the relative preservation potential of two key feather components, melanosomes and keratinous tissue, is not fully resolved. Recent studies suggesting that melanosomes...

article

Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor‐intact or heterozygous skin

Robert‐Marlo Bautista, Katharine Marie Carter, Stuart Gordon Jarrett, Dana Napier, more

Pigment Cell & Melanoma Research > 33 > 1 > 30 - 40

Homozygous loss of function of the melanocortin 1 receptor (MC1R) is associated with a pheomelanotic pigment phenotype and increased melanoma risk. MC1R heterozygosity is less well studied, although individuals inheriting one loss‐of‐function MC1R allele are also melanoma‐prone. Using the K14‐Scf C57BL/6J animal model whose skin is characterized by lifelong retention of interfollicular epidermal melanocytes...

article

Tyrosinase‐catalyzed oxidation of resveratrol produces a highly reactive ortho‐quinone: Implications for melanocyte toxicity

Shosuke Ito, Yui Fujiki, Nina Matsui, Makoto Ojika, more

Pigment Cell & Melanoma Research > 32 > 6 > 766 - 776

trans‐Resveratrol (3,5,4′‐trihydroxy‐trans‐stilbene, RES), a naturally occurring polyphenol, has recently attracted increased interest as a health‐beneficial agent. However, based on its p‐substituted phenol structure, RES is expected to be a substrate for tyrosinase and to produce a toxic o‐quinone metabolite. The results of this study demonstrate that the oxidation of RES by tyrosinase produces...

article

Photobleaching of pheomelanin increases its phototoxic potential: Physicochemical studies of synthetic pheomelanin subjected to aerobic photolysis

Andrzej Zadlo, Grzegorz Szewczyk, Michal Sarna, Theodore G. Camenisch, more

Pigment Cell & Melanoma Research > 32 > 3 > 359 - 372

Although melanin is a photoprotective pigment, its elevated photochemical reactivity could lead to various phototoxic processes. Photoreactivity of synthetic pheomelanin, derived from 5‐S‐cysteinyldopa (5SCD‐M) and its photodegradation products obtained by subjecting the melanin to aerobic irradiation with UV‐visible light, was examined employing an array of advanced physicochemical methods. Extensive...

article

Visible light accelerates the ultraviolet A‐induced degradation of eumelanin and pheomelanin

Shosuke Ito, Ludger Kolbe, Gudrun Weets, Kazumasa Wakamatsu

Pigment Cell & Melanoma Research > 32 > 3 > 441 - 447

Exposure to excess ultraviolet (UV) A radiation induces the degradation/modification of both eumelanin and pheomelanin that may be deleterious to pigmented tissues. Although the spectral distribution of solar energy comprises nearly half of visible light (VL), few studies have been conducted to examine the role of VL in the photodegradation of both types of melanin, either VL alone or in combination...

article

Evolution of short tails and breakdown of honest signaling system during a severe winter in the Pacific swallow Hirundo tahitica

Masaru Hasegawa, Emi Arai, Shosuke Ito, Kazumasa Wakamatsu

Evolutionary Ecology > 2019 > 33 > 3 > 403-416

In dynamic selection regimes, an honest signal that indicates high quality in favorable environments might be negatively related to quality in unfavorable environments, though empirical evidence is scarce. Here, we studied the relationship between plumage ornaments and physiological state in the Pacific swallow Hirundo tahitica on Amami Oshima Island in 2 years with contrasting weather conditions:...

article

4‐(4‐Hydroxyphenyl)‐2‐butanol (rhododendrol)‐induced melanocyte cytotoxicity is enhanced by UVB exposure through generation of oxidative stress

Noriko Goto, Mariko Tsujimoto, Hiroshi Nagai, Taro Masaki, more

Experimental Dermatology > 27 > 7 > 754 - 762

4‐(4‐Hydroxyphenyl)‐2‐butanol (rhododendrol, RD), a skin‐whitening agent, was reported to cause skin depigmentation in some users, which is attributed to its cytotoxicity to melanocyte. It was reported that cytotoxicity to melanocyte is possibly mediated by oxidative stress in a tyrosinase activity‐dependent manner. We examined the effect of UV radiation (UVR) on RD‐induced melanocyte cytotoxicity...

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INFONA - science communication portal

Search results for: Shosuke Ito

2‐Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity

Genetic insights into Tietz albinism‐deafness syndrome: A new dominant‐negative mutation in MITF

Cytoglobin functions as a redox regulator of melanogenesis in normal epidermal melanocytes

Cyclic oscillations in melanization within Hystrix porcupine quills

Impact of a SLC24A5 variant on the retinal pigment epithelium of a Japanese patient with oculocutaneous albinism type 6

Photobleached Oxidative Degradation of Melanins: Chemical Characterization of Melanins Present in Alpaca Fiber

Special issue: “Biology of skin pigmentation and pigmentary diseases”

Chemical and biochemical control of skin pigmentation with special emphasis on mixed melanogenesis

Rhododendrol‐induced leukoderma update II: Pathophysiology, mechanisms, risk evaluation, and possible mechanism‐based treatments in comparison with vitiligo

Rhododendrol‐induced leukoderma update I: Clinical findings and treatment

Application of mid‐infrared free‐electron laser for structural analysis of biological materials

Establishment of a mouse model for post‐inflammatory hyperpigmentation

Kojic acid alters pheomelanin content in human induced pluripotent stem cell‐derived melanocytes

Taphonomic experiments resolve controls on the preservation of melanosomes and keratinous tissues in feathers

Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor‐intact or heterozygous skin

Tyrosinase‐catalyzed oxidation of resveratrol produces a highly reactive ortho‐quinone: Implications for melanocyte toxicity

Photobleaching of pheomelanin increases its phototoxic potential: Physicochemical studies of synthetic pheomelanin subjected to aerobic photolysis

Visible light accelerates the ultraviolet A‐induced degradation of eumelanin and pheomelanin

Evolution of short tails and breakdown of honest signaling system during a severe winter in the Pacific swallow Hirundo tahitica

4‐(4‐Hydroxyphenyl)‐2‐butanol (rhododendrol)‐induced melanocyte cytotoxicity is enhanced by UVB exposure through generation of oxidative stress

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