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Introduction
Immunogenicity causing development of anti‐drug antibodies (ADAs) are major challenges in the treatment of haemophilia, as well as other diseases where proteins are used for treatment. Furthermore, it is a complication for preclinical testing of such therapies in animal models.
Aim
To investigate if the immunosuppressive drug CTLA4 immunoglobulin (CTLA4‐Ig) can induce tolerance in...
Background
Haemophilic arthropathy is the main morbidity of haemophilia. The individual pathological response to the same number of clinically evident joint bleeds is highly variable; thus, it remains unknown if certain joint bleeding characteristics are critical for the development of arthropathy.
Aim
To study the relation between bleed volume and subsequent development of arthropathy, we aimed...
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