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Multiple sclerosis (MS) is a central nervous system disease characterized by both degenerative and inflammatory processes. Various mediators are involved in the interplay of degeneration and innate immunity on one hand and peripheral adaptive immunity on the other hand. The secreted protein lipocalin 2 (LCN2) is an inflammatory modulator in a variety of pathologies. Although elevated intrathecal levels...
Cover Illustration: Lipocalin 2 is a potential regulator of inflammation in the brain and possibly involved in Multiple Sclerosis (MS) lesion formation. The picture was taken from tissue obtained from an MS patient with progressive disease course. The maximum projection identifies intracellular Lipocalin 2 (green) within an activated astrocyte (GFAP in red). (See Gasterich, N. et al, https://doi.org/10...
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