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Objective
Improving the identification of the epileptogenic zone and associated seizure‐spreading regions represents a significant challenge. Innovative brain‐imaging modalities tracking neurovascular dynamics during seizures may provide new disease biomarkers.
Methods
With use of a multi‐parametric magnetic resonance imaging (MRI) analysis at 9.4 Tesla, we examined, elaborated, and combined multiple...
Objective
Following surgery, focal seizures relapse in 20% to 50% of cases due to the difficulty of delimiting the epileptogenic zone (EZ) by current imaging or electrophysiological techniques. Here, we evaluate an unbiased metabolomics approach based on ex vivo and in vivo nuclear magnetic resonance spectroscopy (MRS) methods to discriminate the EZ in a mouse model of mesiotemporal lobe epilepsy...
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