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Antibodies to glutamic acid decarboxylase (GAD), the major pathway for the synthesis of γ‐aminobutyric acid (GABA) in humans, are found at elevated levels in a subgroup of patients with chronic epilepsy. To test whether the antibodies were associated with changes in cortical GABA levels we used magnetic resonance spectroscopy. Four patients with epilepsy and high serum GAD antibody levels (107–6,200...