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Solid‐state nanopore based biosensors are cost effective, high‐throughput engines for single molecule detection of biomolecules with the added benefit of size modification. Progress in the translation of the science into a viable diagnostic tool is impeded by inadequate sensitivity of data acquisition systems in detection of fast DNA translocations through the pore. To combat this, slowing the transport...
DOI: 10.1002/elps.201800426
The cover picture shows a single molecule of double stranded DNA electrophoretically transporting through a solid state nanopore in a SiNx membrane. Attached to the DNA are Li molecules which compose the experimental buffer and actively slow transport of the DNA. Transport is further slowed by applying a salt gradient between the cis and trans side of the membrane, denoted...
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