Search results for: Eckart Förster

Items from 1 to 18 out of 18 results

article

Reelin signaling modulates GABA_B receptor function in the neocortex

Mohammad I. K. Hamad, Abdalrahim Jbara, Obada Rabaya, Petya Petrova, more

Journal of Neurochemistry > 156 > 5 > 589 - 603

Reelin is a protein that is best known for its role in controlling neuronal layer formation in the developing cortex. Here, we studied its role for post‐natal cortical network function, which is poorly explored. To preclude early cortical migration defects caused by Reelin deficiency, we used a conditional Reelin knock‐out (Reln^cKO) mouse, and induced Reelin deficiency post‐natally. Induced Reelin...

article

High level of CTP synthase induces formation of cytoophidia in cortical neurons and impairs corticogenesis

Xuzhao Li, Jiongfang Xie, Maofang Hei, Jianli Tang, more

Histochemistry and Cell Biology > 2018 > 149 > 1 > 61-73

De novo synthesis of the nucleotide CTP is catalyzed by the essential pyrimidine biosynthesis enzyme CTP synthase (CTPs), which forms large-scale filamentous structures consisting of CTPs termed cytoophidia in prokaryotes and in eukaryotes. Recent studies have shown that cytoophidia are abundant in neuroepithelial stem cells in Drosophila optic lobes and that overexpression of CTPs impairs optic lobe...

article

Dexamethasone and levetiracetam reduce hetero-cellular gap-junctional coupling between F98 glioma cells and glial cells in vitro

Fatme Seval Ismail, Zahra Moinfar, Nora Prochnow, Hannes Dambach, more

Journal of Neuro-Oncology > 2017 > 131 > 3 > 469-476

Gap junctions (GJs) in astrocytes and glioma cells are important channels for cell-to-cell communication that contribute to homo- and heterocellular coupling. According to recent studies, heterocellular gap-junctional communication (H-GJC) between glioma cells and their surrounding environment enhances glioma progression. Therefore, we developed a new in vitro model to examine H-GJC between glioma...

article

Goethe and the “Auge des Geistes”

Eckart Förster

Deutsche Vierteljahrsschrift für Literaturwissenschaft und Geistesgeschichte > 2001 > 75 > 1 > 87-101

In this paper I investigate the philosophical significance of Goethe’s frequent talk of “the eye of the mind” and examine what role it plays in the context of his scientific methodology.

article

Distribution pattern and penetration depth of doxorubicin after pressurized intraperitoneal aerosol chemotherapy (PIPAC) in a postmortem swine model

Veria Khosrawipour, Tanja Khosrawipour, Alexander Jens Peter Kern, Aras Osma, more

Journal of Cancer Research and Clinical Oncology > 2016 > 142 > 11 > 2275-2280

Background Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel approach delivering intraperitoneal chemotherapy by means of a pressurized aerosol. This study was conducted to evaluate the distribution pattern of doxorubicin in the abdominal cavity after PIPAC in a postmortem swine model. Methods Doxorubicin was aerosolized through a Micropump© (MIP) into the peritoneal cavity of...

article

Exploring the Spatial Drug Distribution Pattern of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)

Veria Khosrawipour, Tanja Khosrawipour, David Diaz-Carballo, Eckart Förster, more

Annals of Surgical Oncology > 2016 > 23 > 4 > 1220-1224

Background Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel approach to delivering intraperitoneal chemotherapy (IPC) as a pressurized aerosol. One of the assumed advantages is the homogeneous drug distribution in the intraperitoneal cavity compared with conventional liquid in situ chemotherapy. However, to date, the spatial drug distribution pattern of PIPAC has not been investigated...

article

Expression and regulation of reelin and its receptors in the enteric nervous system

Martina Böttner, Puya Ghorbani, Jonas Harde, Martina Barrenschee, more

Molecular and Cellular Neuroscience > 2014 > 61 > C > 23-33

In the central nervous system (CNS), reelin coordinates migration and lamination of neurons and regulates synaptic plasticity, whereas its role in the enteric nervous system (ENS) remains enigmatic. Thus we determined the expression pattern and localization of reelin in the human ENS and monitored the time course of mRNA expression of the reelin signaling system in the rat intestine as well as in...

article

Reelin and the Cdc42/Rac1 guanine nucleotide exchange factor αPIX/Arhgef6 promote dendritic Golgi translocation in hippocampal neurons

Maurice Meseke, Georg Rosenberger, Eckart Förster

European Journal of Neuroscience > 37 > 9 > 1404 - 1412

In the cerebral cortex of reeler mutant mice lacking reelin expression, neurons are malpositioned and display misoriented apical dendrites. Neuronal migration defects in reeler have been studied in great detail, but how misorientation of apical dendrites is related to reelin deficiency is poorly understood. In wild‐type mice, the Golgi apparatus transiently translocates into the developing apical...

article

A 3D‐matrigel/microbead assay for the visualization of mechanical tractive forces at the neurite–substrate interface of cultured neurons

Maurice Meseke, Eckart Förster

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 101A > 6 > 1726 - 1733

Mechanical properties of neuronal processes contribute to neuronal function, to resistance of fiber tracts against mechanical trauma, and to morphological changes during development and neurodegeneration. Conventional in vitro cell culture systems on inflexible substrates do not allow for the visualization of changing mechanical stress between neurites and their substrate. To solve this problem, we...

article

Reelin promotes microtubule dynamics in processes of developing neurons

Maurice Meseke, Ersin Cavus, Eckart Förster

Histochemistry and Cell Biology > 2013 > 139 > 2 > 283-297

The extracellular matrix protein reelin controls radial migration and layer formation of cortical neurons, in part by modulation of cytoskeletal dynamics. A stabilizing effect of reelin on the actin cytoskeleton has been described recently. However, it is poorly understood how reelin modulates microtubule dynamics. Here, we provide evidence that reelin increases microtubule assembly. This effect is...

article

Congruence of vascular network remodeling and neuronal dispersion in the hippocampus of reelin-deficient mice

Tina Lindhorst, Haymo Kurz, Mirjam Sibbe, Maurice Meseke, more

Histochemistry and Cell Biology > 2012 > 137 > 5 > 629-639

In the hippocampus, neurons and fiber projections are strictly organized in layers and supplied with oxygen via a vascular network that also develops layer-specific characteristics in wild-type mice, as shown in the present study for the first time in a quantitative manner. By contrast, in the reeler mutant, well known for its neuronal migration defects due to the lack of the extracellular matrix...

article

Emerging topics in Reelin function

Eckart Förster, Hans H. Bock, Joachim Herz, Xuejun Chai, more

European Journal of Neuroscience > 31 > 9 > 1511 - 1518

Reelin signalling in the early developing cortex regulates radial migration of cortical neurons. Later in development, Reelin promotes maturation of dendrites and dendritic spines. Finally, in the mature brain, it is involved in modulating synaptic function. In recent years, efforts to identify downstream signalling events induced by binding of Reelin to lipoprotein receptors led to the characterization...

article

Exogenous reelin prevents granule cell dispersion in experimental epilepsy

Martin C. Müller, Matthias Osswald, Stefanie Tinnes, Ute Häussler, more

Experimental Neurology > 2009 > 216 > 2 > 390-397

Temporal lobe epilepsy (TLE) is often accompanied by granule cell dispersion (GCD), a migration defect of granule cells in the dentate gyrus. We have previously shown that a decrease in the expression of reelin, an extracellular matrix protein important for neuronal positioning, is associated with the development of GCD in TLE patients. Here, we used unilateral intrahippocampal injection of kainate...

article

Role of Reelin in the development and maintenance of cortical lamination

Michael Frotscher, Xuejun Chai, Hans H. Bock, Carola A. Haas, more

Journal of Neural Transmission > 2009 > 116 > 11 > 1451-1455

Reelin is a large extracellular matrix molecule, synthesized by early generated Cajal–Retzius cells in the marginal zone of the cortex. It plays an important role in the migration of cortical neurons and the development of cortical lamination. We recently discovered that Reelin is required not only for the formation of cortical layers during development but also for their maintenance in adulthood...

article

Fyn Tyrosine Kinase Is a Critical Regulator of Disabled-1 during Brain Development

Lionel Arnaud, Bryan A. Ballif, Eckart Förster, Jonathan A. Cooper

Current Biology > 2003 > 13 > 1 > 9-17

Background: Disabled-1 (Dab1) is an intracellular adaptor protein that regulates migrations of various classes of neurons during mammalian brain development. Dab1 function depends on its tyrosine phosphorylation, which is stimulated by Reelin, an extracellular signaling molecule. Reelin increases the stoichiometry of Dab1 phosphorylation and downregulates Dab1 protein levels. Reelin binds to various...

article

Dentate Granule Cells in Reeler Mutants and VLDLR and ApoER2 Knockout Mice

Alexander Drakew, Thomas Deller, Bernd Heimrich, Carl Gebhardt, more

Experimental Neurology > 2002 > 176 > 1 > 12-24

We have studied the organization and cellular differentiation of dentate granule cells and their axons, the mossy fibers, in reeler mutant mice lacking reelin and in mutants lacking the reelin receptors very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2). We show that granule cells in reeler mice do not form a densely packed granular layer, but are loosely distributed...

article

The Hippocampus of the Reeler Mutant Mouse: Fiber Segregation in Area CA1 Depends on the Position of the Postsynaptic Target Cells

Thomas Deller, Alexander Drakew, Bernd Heimrich, Eckart Förster, more

Experimental Neurology > 1999 > 156 > 2 > 254-267

Area CA1 of the rodent hippocampus is characterized by a highly lamina-specific and nonoverlapping termination of afferent fiber tracts. Entorhinal fibers terminate in stratum lacunosum-moleculare and commissural/associational fibers terminate in strata radiatum and oriens. It has been hypothesized that this fiber lamination depends on specific signals for the different afferent fiber tracts that...

article

Survival, regeneration and sprouting of central neurons: the rat septohippocampal projection as a model

Michael Frotscher, Thomas Deller, Bernd Heimrich, Eckart Förster, more

Annals of Anatomy > 1996 > 178 > 4 > 311-315

The septohippocampal projection was used to study the survival following axotomy, axonal regeneration, and sprouting of a defined group of central neurons. Septohippocampal projection neurons in adult rats were axotomized by bilateral lesions of the fimbria-fornix. Using prelabeling prior to axotomy, intracellular staining, electron microscopy, and immunocytochemical and in situ hybridization techniques,...

Filter options

Publication date

Set your own date range

Keywords

REELIN (6)
NEURONAL MIGRATION (5)
DAB1 (2)
DENTATE GYRUS (2)
192-IGG SAPORIN (1)
ACTIN CYTOSKELETON (1)
ADULT NEUROGENESIS (1)
ALVEAR PATH. (1)
AMMON'S HORN SCLEROSIS (1)
AMYLOID PRECURSOR PROTEIN (1)
APOER2 (1)
APOER2 AND VLDLR (1)
ASTROCYTES (1)
AXONAL PATHFINDING (1)
CAJAL–RETZIUS CELLS (1)
CALCIUM IMAGING (1)
CELL CULTURE (1)
CHOLINE ACETYLTRANSFERASE (1)
COFILIN (1)
COMMISSURAL FIBERS (1)
CORTICAL DEVELOPMENT (1)
CORTICOGENESIS (1)
CTPS (1)
CYTOOPHIDIA (1)
DENDRITIC GOLGI (1)
DEXAMETHASONE (1)
ENTERIC NERVOUS SYSTEM (1)
ENTORHINAL FIBERS (1)
EX VIVO SWINE (1)
EXTRACELLULAR MATRIX (1)
GABAB RECEPTORS (1)
GLIOMA (1)
GOLGI APPARATUS (1)
GRANULE CELL DISPERSION (1)
HETEROCELLULAR GAP JUNCTIONS (1)
HIPPOCAMPAL ANGIOGENESIS (1)
HIPPOCAMPAL DEVELOPMENT (1)
IN UTERO ELECTROPORATION (1)
INTRAPERITONEAL CHEMOTHERAPY (1)
LAYER-SPECIFICITY (1)
LEVETIRACETAM (1)
LTP (1)
MATRIGEL (1)
MICROGLIA (1)
MICROTUBULE ASSEMBLY (1)
MICROTUBULE PLUS END BINDING PROTEIN 3 (1)
MICROTUBULES (1)
MIGRATION DEFECTS (1)
MOSSY FIBERS (1)
MOUSE MUTANTS (1)
NERVE GROWTH FACTOR (1)
NETWORK ACTIVITY (1)
NEUROGENESIS (1)
NEURONAL POLARITY (1)
NMDA‐RECEPTOR (1)
P75 RECEPTOR (1)
PERITONEAL CARCINOMATOSIS (1)
PIPAC (1)
PYRAMIDAL CELLS (1)
RADIAL MIGRATION (1)
REELER (1)
REELIN RECEPTOR (1)
REELIN RECEPTORS (1)
REELIN SIGNALLING (1)
RHO GTPASE (1)
SEPTAL CHOLINERGIC NEURONS (1)
SLICE CULTURE (1)
SOMA TRANSLOCATION (1)
SYNAPTIC PLASTICITY (1)
SYNAPTOGENESIS (1)
TEMPORAL LOBE EPILEPSY (1)
TRKA RECEPTOR (1)
VERY LOW DENSITY LIPOPROTEIN RECEPTOR (1)
VLDLR (1)
WHOLE ABDOMINAL RADIATION (1)
Α-TUBULIN (1)
ΒPIX (1)
more

Data set

Springer (8)
Elsevier (6)
Wiley (4)

INFONA - science communication portal

Search results for: Eckart Förster

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options