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CD4+ T‐cell subtypes govern the synthesis of different Ab isotypes and other immune functions. The influence of CD4+ T‐cell differentiation programs on isotype switching and other aspects of host immunological networks during malaria infection are currently poorly understood. Here, we used Tbx21−/− mice deficient for T‐bet, a regulator of Th1 CD4+ T‐cell differentiation, to examine the effect of Th1...