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The impact of cigarette smoke (CS), a risk factor for rheumatoid arthritis (RA), on sauto‐antibody production was studied in humans and mice with and without chronic lung disease (LD). Rheumatoid factor (RF), anti‐cyclic citrullinated peptides (CCPs), and anti‐HSP70 autoantibodies were measured in several mouse strains and in cohorts of smokers and nonsmokers with and without autoimmune disease. Chronic...