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We show that IL-36R is expressed by T (CD4+ and CD8+) and B (CD19+) lymphocytes in human blood and also by CD4+ T lymphocytes in the intestinal lamina propria. IL-36R protein was mostly stored in the cytoplasm of CD4 lymphocytes and B cells, during steady state conditions and the greatest expression of IL-36R mRNA was measured in CD4+ (T helper) lymphocytes. IL-36 β, which functions via IL-36R induced...
We show that IL-36α induced maturation of human MDDCs and stimulated differentiation of IFN-γ producing (Type 1) CD3+ lymphocytes but was not as effective as IL-36β in doing so. For the first time, we also show that IL-36α induced expression of CD14 by MDDCs and this was highly potentiated by co-cultured with IFN-γ. In contrast, lipopolysaccharide (LPS) did not increase CD14 expression by MDDCs, suggesting...
We report for the first time that expression of the novel IL‐1 cytokine receptor IL‐1Rrp2 (IL‐1R6) is unique to DCs within the human myelomonocytic lineage. IL‐1Rrp2 was expressed by monocyte‐derived dendritic cells (MDDCs) which was dose‐dependently increased by IL‐4 and correlated with increased numbers of differentiated MDDCs. Human plasmacytoid DCs also express IL‐1Rrp2 but the receptor is not...
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