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Phagocytic removal of apoptotic lymphocytes exacerbates replication of Trypanosoma cruzi in macrophages. We investigated the presence of Ab against apoptotic lymphocytes in T. cruzi infection and the role of these Ab in parasite replication. Both control and chagasic serum contained IgG Ab that opsonized apoptotic lymphocytes. Treatment of apoptotic lymphocytes with purified IgG from chagasic, but...
Caspases, a family of cysteinyl–aspartate-specific proteases, induce apoptosis but are also involved in signal transduction in live cells. Caspase activation and apoptosis in T lymphocytes occur following infection with parasites and might affect immune responses. Rapid progress has occurred in the development and testing of caspase inhibitors and other apoptosis blockers, which are potentially useful...
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