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For patients with metastatic pancreatic adenocarcinoma, there are no approved or established treatments beyond the 2nd line. A Phase Ib study of fractionated radioimmunotherapy was undertaken in this setting, administering 90Y-clivatuzumab tetraxetan (yttrium-90-radiolabelled humanised antibody targeting pancreatic adenocarcinoma mucin) with or without low radiosensitising doses of gemcitabine.Fifty-eight...
BACKGROUND:It has been demonstrated that the humanized clivatuzumab tetraxetan (hPAM4) antibody targets pancreatic ductal carcinoma selectively. After a trial of radioimmunotherapy that determined the maximum tolerated dose of single‐dose yttrium‐90‐labeled hPAM4 (90Y‐hPAM4) and produced objective responses in patients with advanced pancreatic ductal carcinoma, the authors studied fractionated radioimmunotherapy...
To show successful treatment of testicular cancer in a community-based setting by following established national guidelines and a multidisciplinary approach that includes postorchiectomy surveillance. The Christiana Care Health System Oncology Data Base and records of treating physicians at the Helen F. Graham Cancer Center were analyzed for patients diagnosed with clinical stages I, II, and III...
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