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Hypoxic adaptation pathways, essential for Candida albicans pathogenesis, are tied to its transition from a commensal to a pathogen. Herein, we identify a WW domain‐containing protein, Ifu5, as a determinant of hypoxic adaptation that also impacts normoxic responses in this fungus. Ifu5 activity supports glycosylation homeostasis via the Cek1 mitogen‐activated protein kinase‐dependent up‐regulation...
Fungal pathogens such as Candida albicans exhibit several survival mechanisms to evade attack by antifungals and colonise host tissues. Rta3, a member of the Rta1‐like family of lipid‐translocating exporters has a 7‐transmembrane domain topology, similar to the G‐protein‐coupled receptors and is unique to the fungal kingdom. Our findings point towards a role for the plasma membrane localised Rta3...
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