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The twigs and leaves of Blepharispermum hirtumOliver (Asteraceae) were investigated for their larvicidal and antimicrobial activity. Fractionation of the extracts of the twigs, directed by brine shrimp test and antibacterial activities, led to the isolation of compounds 1–4; two of which are new ent‐kaurene diterpenoids, blepharispins A and B (1 and 2, resp.). The structures of compounds 1 and 2 were...