Search results for: Tho Huu Le

Items from 1 to 6 out of 6 results

article

Discovery of Alkyl Triphenylphosphonium Pinostrobin Derivatives as Potent Anti‐Breast Cancer Agents

Tu Hoai Tran, Tho Huu Le, Thu‐Ha Thi Nguyen, Long Binh Vong, more

Chemistry & Biodiversity > 21 > 7 > n/a - n/a

Pinostrobin demonstrated anticancer properties, but its hydrophobic feature led to a reduction in bioavailability. The mitochondria‐targeted approach successfully synthesized eight new alkyl triphenylphosphonium pinostrobin derivatives (1–8) with good yield in this study. Seven compounds (1–3, 5–8) showed greater cytotoxic potency against the human MCF‐7 breast cancer cell line than pinostrobin. Molecular...

article

A New abeo‐Icetexane‐Type Diterpenoid from the Stem Barks of Taxus wallichiana

Phu Hoang Dang, Hai Xuan Nguyen, Tho Huu Le, Truong Nhat Van Do, more

Chemistry & Biodiversity > 19 > 12 > n/a - n/a

From a CH₂Cl₂‐soluble fraction of the stem barks of Taxus wallichiana, one new abeo‐icetexane‐type diterpenoid, taxamairin I (1), was isolated. Its absolute configuration was elucidated based on spectroscopic interpretation and time‐dependent density functional theory (TD‐DFT) calculation of optical rotation. In addition, the plausible biosynthesis pathway for the formation of the new abeo‐icetexane‐type...

article

Two new compounds and α-glucosidase inhibitors from the leaves of Bidens pilosa L.

Truong Van Nguyen Thien, Vi Ha Thi Huynh, Loan Kieu Thi Vo, Nhan Trong Tran, more

Phytochemistry Letters > 2017 > 20 > C > 119-122

From the leaves of Bidens pilosa L., the n-hexane, chloroform, and aqueous extracts exhibited in vitro α-glucosidase inhibitory activity, with IC₅₀ values of 235.8, 125.6, and 100.3μg/mL, respectively. Two new compounds, methyl 4-O-caffeoyl-2-C-methyl-d-erythronate (1) and 4-O-methylokanin (2), and seven known compounds were isolated from these extracts. The chemical structures of 1–9 were elucidated...

article

Tyrosinase inhibitory activity of flavonoids from Artocarpus heterophyllous

Hai Xuan Nguyen, Nhan Trung Nguyen, Mai Ha Khoa Nguyen, Tho Huu Le, more

Chemistry Central Journal > 2016 > 10 > 1 > 1-6

Background Tyrosinase is an oxidoreductase that is very important in medicine and cosmetics because the excessive production of melanin causes hyperpigmentation. The development of novel, effective tyrosinase inhibitors has long been pursued. In preliminary tests, we found that an extract of the wood of Artocarpus heterophyllous (AH) potently inhibited tyrosinase activity. Results Two new flavonoids,...

article

α-Glucosidase inhibitors from the bark of Mangifera mekongensis

Hai Xuan Nguyen, Tri Cong Le, Truong Nhat Van Do, Tho Huu Le, more

Chemistry Central Journal > 2016 > 10 > 1 > 1-6

Background Mangifera mekongensis (Anacardiaceae) is cultivated for its edible fruit and has been used in traditional Vietnamese medicine for its anti-aging properties and for treating diabetes, vermifuge, and dysentery. As part of a search for biologically active compounds with reduction of the rate of glucose absorption, a screening has been initiated to evaluate natural product extracts...

article

α-Glucosidase inhibitors from the leaves of Embelia ribes

Phu Hoang Dang, Nhan Trung Nguyen, Hai Xuan Nguyen, Luan Bao Nguyen, more

Fitoterapia > 2015 > 100 > Complete > 201-207

A novel and rare 1,4-dehydrated ceramide, embelamide (1), and a new C-glycoalkaloid which is based on a β-carboline ring system, 1-(2′-deoxy-α-d-ribopyranosyl)-β-carboline (4), were isolated from the CHCl ₃ soluble fraction of the leaves of Embelia ribes (Myrsinaceae), together with thirteen known compounds (2–3, 5–15). Their structures were elucidated on the basis of spectroscopic data. Compounds...

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Search results for: Tho Huu Le

Discovery of Alkyl Triphenylphosphonium Pinostrobin Derivatives as Potent Anti‐Breast Cancer Agents

A New abeo‐Icetexane‐Type Diterpenoid from the Stem Barks of Taxus wallichiana

Two new compounds and α-glucosidase inhibitors from the leaves of Bidens pilosa L.

Tyrosinase inhibitory activity of flavonoids from Artocarpus heterophyllous

α-Glucosidase inhibitors from the bark of Mangifera mekongensis

α-Glucosidase inhibitors from the leaves of Embelia ribes

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