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Anti‐mullerian hormone (AMH) is one of the least studied members of transforming growth factor beta superfamily showing pro‐apoptotic activity against cells positive for hormone type II receptor overexpressed by malignant cells in many cancer cases. Here, we propose an improved method for isolation of recombinant C‐terminal AMH fragment (C‐rAMH) to obtain homogeneous preparations of this protein with...
Anti‐mullerian hormone (AMH) is a cytokine of transforming growth factor β (TGF‐β) superfamily able to induce apoptosis in cells bearing specific AMH type II receptors (AMHRII). AMHRII is overexpressed in some malignant cells, so at present recombinant AMH (rAMH) is considered as a new candidate antineoplastic drug. The use of rAMH may be especially effective in case of such severe diseases as ovarian,...
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