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Regenerative Medicine
Extracellular vesicles from healthy human platelets globally control inflammation in the hearts of mice with viral myocarditis by regulating the innate immune response with their heterogenous functional contents. This immunomodulation in part comes from anti‐inflammatory microRNAs and prevents cardiac dysfunction during peak acute myocarditis. The therapeutic tested in article...
Patients with viral myocarditis are at risk of sudden death and may progress to dilated cardiomyopathy (DCM). Currently, no disease‐specific therapies exist to treat viral myocarditis. Here it is examined whether reconstituted, lyophilized extracellular vesicles (EVs) from platelets from healthy men and women reduce acute or chronic myocarditis in male mice. Human‐platelet‐derived EVs (PEV) do not...
The contributions of the innate immune system to the development of pancreatic cancer are still ill defined. Inflammatory macrophages can initiate metaplasia of pancreatic acinar cells to a duct-like phenotype (acinar-to-ductal metaplasia [ADM]), which then gives rise to pancreatic intraepithelial neoplasia (PanIN) when oncogenic KRas is present. However, it remains unclear when and how this inflammatory...
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