J.W. Fluhr

article

Disease severity, patient‐reported outcomes and skin hydration improve during balneotherapy with hydrocarbonate‐ and sulphur‐rich water of psoriasis

R. Darlenski, I. Bogdanov, M. Kacheva, D. Zheleva, more

Journal of the European Academy of Dermatology and Venereology > 35 > 3 > e196 - e198

article

Pathophysiology and management of sensitive skin: position paper from the special interest group on sensitive skin of the International Forum for the Study of Itch (IFSI)

L. Misery, E. Weisshaar, E. Brenaut, A.W.M. Evers, more

Journal of the European Academy of Dermatology and Venereology > 34 > 2 > 222 - 229

The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of...

article

Characterization of cowhage‐induced pruritus in inflamed and non‐inflamed skin

F. André, J.W. Fluhr, T. Hawro, M.K. Church, more

Journal of the European Academy of Dermatology and Venereology > 34 > 1 > 202 - 206

Background and objective Pruritus is a major symptom of many inflammatory diseases and impacts greatly the quality of life in patients. We aimed to specify the characteristics of experimentally induced pruritus in normal skin and in experimentally induced inflammatory dermatitis in healthy volunteers. Methods Skin inflammation was induced by the repeated application of sodium lauryl sulphate (SLS...

article

Assessment of a scoring system for Basal Cell Carcinoma with multi‐beam optical coherence tomography

C. Wahrlich, S.A. Alawi, S. Batz, J.W. Fluhr, more

Journal of the European Academy of Dermatology and Venereology > 29 > 8 > 1562 - 1569

BackgroundMulti‐beam optical coherence tomography (OCT) is a novel method of non‐invasive skin imaging allowing the evaluation of tissue at high level of lateral and axial resolution. It permits the horizontal and vertical evaluation of the extent of diseases. ObjectiveHerein, we aimed to validate diagnosing basal cell carcinoma (BCC) by OCT using a newly developed scoring system (‘Berlin Score’‐BS)...

article

Allergic contact dermatitis in mice is not affected or penetrated by ahaps-functionaliZed silica nanoparticles

A. Ostrowski, D. Nordmeyer, L. Mundhenk, J.W. Fluhr, more

Journal of Comparative Pathology > 2015 > 152 > 1 > 78-79

article

Medizinkarawane in Marokko

J.W. Fluhr, C. Mockel-Kocks

Der Hautarzt > 2015 > 66 > 5 > 342-346

Der vorliegende Beitrag soll die Erfahrungen der Teilnahme an mehreren „Medizinkarawanen“ widerspiegeln. Diese wurden entweder von einer marokkanischen Nichtregierungsorganisationen (NRO) oder von einer belgischen NRO durchgeführt. Medizinkarawanen sind multidisziplinäre mobile Gruppen, die in ländlichen Gebieten die medizinische Basisversorgung übernehmen. Dabei wird der Ort für die Versorgung alle...

article

Development and organization of human stratum corneum after birth: electron microscopy isotropy score and immunocytochemical corneocyte labelling as epidermal maturation's markers in infancy

J.W. Fluhr, N. Lachmann, C. Baudouin, P. Msika, more

British Journal of Dermatology > 171 > 5 > 978 - 986

BackgroundThere is growing evidence for the ongoing structural and functional adaptation of the skin after birth. ObjectivesThe aim of this study was the definition of scanning electron microscopy markers of skin maturation in different age groups (birth to adulthood). We propose a semiquantitative score to analyse the maturation of the skin surface and a complementary evaluation of the distribution...

article

Encapsulated curcumin results in prolonged curcumin activity in vitro and radical scavenging activity ex vivo on skin after UVB-irradiation

N. Suwannateep, S. Wanichwecharungruang, S.F. Haag, S. Devahastin, more

European Journal of Pharmaceutics and Biopharmaceutics > 2012 > 82 > 3 > 485-490

The phytochemical curcumin possesses antioxidant activity; however, it becomes unstable after being exposed to light or heat or loses activity during storage. This is especially important when curcumin is applied to the skin within a cosmetic or pharmaceutical formulation, since sun exposure is unavoidable. This drawback can be directly addressed by encapsulation of curcumin in photo-stable nanospheres...

article

Non-invasive analysis of penetration and storage of Isoconazole nitrate in the stratum corneum and the hair follicles

J. Lademann, A. Patzelt, S. Schanzer, H. Richter, more

European Journal of Pharmaceutics and Biopharmaceutics > 2012 > 80 > 3 > 615-620

Bacteria and fungi are located in the stratum corneum and the hair follicles. Therefore, the development and assessment of efficient drugs requires standard in vivo investigation methods permitting a differentiation between intercellular and follicular penetration and storage of topically applied anti-microbial substances.In the present study, the penetration and storage of Isoconazole nitrate in...

article

Infant epidermal skin physiology: adaptation after birth

J.W. Fluhr, R. Darlenski, N. Lachmann, C. Baudouin, more

British Journal of Dermatology > 166 > 3 > 483 - 490

Background Functional and structural skin adaptation is a dynamic process which starts immediately after birth in humans and in mammalian skin in general. This adjustment to the extrauterine dry environment is accomplished in the first year of postnatal life of humans. Objectives To assess the dynamic changes in vivo after birth in the molecular composition and skin physiology parameters compared...

article

Two‐color Raman spectroscopy for the simultaneous detection of chemotherapeutics and antioxidative status of human skin

W. Werncke, I. Latka, S. Sassning, B. Dietzek, more

Laser Physics Letters > 8 > 12 > 895 - 900

Aiming at the development of strategies to prevent the hand‐foot‐syndrome, we propose to evaluate the amount of chemotherapeutics in the human skin together with carotenoids the latter serving as marker substances for the dermal antioxidative status. This approach is demonstrated by applying two‐color Raman spectroscopy at 785 and 532 nm excitation for selective detection of chemotherapeutics and...

article

Maintenance therapy: acne as a chronic disease

J.W. Fluhr, A. Nast

British Journal of Dermatology > 164 > 6 > 1181 - 1182

article

Topical retinoids in the management of photodamaged skin: from theory to evidence‐based practical approach

R. Darlenski, C. Surber, J.W. Fluhr

British Journal of Dermatology > 163 > 6 > 1157 - 1165

Skin, being exposed directly to the environment, represents a unique model for demonstrating the synergistic effects of intrinsic and extrinsic factors on the ageing process. Ultraviolet radiation (UVR) is the major factor among exogenous stressors responsible for premature skin ageing. The problem of skin ageing has captured public attention and has an important social impact. Different therapeutic...

article

Non-invasive in vivo methods for investigation of the skin barrier physical properties

R. Darlenski, S. Sassning, N. Tsankov, J.W. Fluhr

European Journal of Pharmaceutics and Biopharmaceutics > 2009 > 72 > 2 > 295-303

Skin as an organ of protection covers the body and accomplishes multiple defensive functions. The intact skin represents a barrier to the uncontrolled loss of water, proteins, and plasma components from the organism. Due to its complex structure, the epidermal barrier with its major component, stratum corneum, is the rate-limiting unit for the penetration of exogenous substances through the skin....

article

The tape stripping procedure – evaluation of some critical parameters

J. Lademann, U. Jacobi, C. Surber, H.-J. Weigmann, more

European Journal of Pharmaceutics and Biopharmaceutics > 2009 > 72 > 2 > 317-323

Tape stripping is a simple and efficient method for the assessment of quality and efficacy of cosmetical and dermatological formulations. After topical application and penetration of formulations, the cell layers of the stratum corneum are successively removed from the same skin area using adhesive films. The tape strips contain the amount of corneocytes and the corresponding amount of the penetrated...

article

Efficacy of different tretinoin formulations under occlusion: TEWL and erythema

L. Lehmann, J.W. Fluhr, M. Clemens, M. Gloor

Journal of the European Academy of Dermatology and Venereology > 1998 > 11 > Supplement 2 > S274

article

In vitro activity of 6 antimicrobials against propionibacteria isolates from untreated acne papulopustulosa

J.W. Fluhr, M. Gloor, P. Dietz, U. Höffler

Journal of the European Academy of Dermatology and Venereology > 1998 > 11 > Supplement 2 > S128

article

Tolerance profile of the 3 topical retinoids: Retinol, retinaldehyde, and retinoic acid

J.W. Fluhr, M.P. Vienne, W. Gehring, M. Gloor, more

Journal of the European Academy of Dermatology and Venereology > 1998 > 11 > Supplement 2 > S210

article

Antibacterial and sebosuppressive efficacy of a combination of topical chloramphenicol and pale sulfonated shale oil in acne papulopustolosa

J.W. Fluhr, M. Gloor, W. Merkel, J. Warnecke, more

Journal of the European Academy of Dermatology and Venereology > 1998 > 11 > Supplement 2 > S187

article

Protective value of bath oils with different solvent characteristics against irritation

J.W. Fluhr, M. Gloor, W. Gehring

Journal of the European Academy of Dermatology and Venereology > 1998 > 11 > Supplement 2 > S133

INFONA - science communication portal

Search results for: J.W. Fluhr

Disease severity, patient‐reported outcomes and skin hydration improve during balneotherapy with hydrocarbonate‐ and sulphur‐rich water of psoriasis

Pathophysiology and management of sensitive skin: position paper from the special interest group on sensitive skin of the International Forum for the Study of Itch (IFSI)

Characterization of cowhage‐induced pruritus in inflamed and non‐inflamed skin

Assessment of a scoring system for Basal Cell Carcinoma with multi‐beam optical coherence tomography

Allergic contact dermatitis in mice is not affected or penetrated by ahaps-functionaliZed silica nanoparticles

Medizinkarawane in Marokko

Development and organization of human stratum corneum after birth: electron microscopy isotropy score and immunocytochemical corneocyte labelling as epidermal maturation's markers in infancy

Encapsulated curcumin results in prolonged curcumin activity in vitro and radical scavenging activity ex vivo on skin after UVB-irradiation

Non-invasive analysis of penetration and storage of Isoconazole nitrate in the stratum corneum and the hair follicles

Infant epidermal skin physiology: adaptation after birth

Two‐color Raman spectroscopy for the simultaneous detection of chemotherapeutics and antioxidative status of human skin

Maintenance therapy: acne as a chronic disease

Topical retinoids in the management of photodamaged skin: from theory to evidence‐based practical approach

Non-invasive in vivo methods for investigation of the skin barrier physical properties

The tape stripping procedure – evaluation of some critical parameters

Efficacy of different tretinoin formulations under occlusion: TEWL and erythema

In vitro activity of 6 antimicrobials against propionibacteria isolates from untreated acne papulopustulosa

Tolerance profile of the 3 topical retinoids: Retinol, retinaldehyde, and retinoic acid

Antibacterial and sebosuppressive efficacy of a combination of topical chloramphenicol and pale sulfonated shale oil in acne papulopustolosa

Protective value of bath oils with different solvent characteristics against irritation

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