Search results for: Thomas G. Koch

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Bioprocess development for cord blood mesenchymal stromal cells on microcarriers in Vertical‐Wheel bioreactors

Erin L. Roberts, Sarah I. M. Lepage, Thomas G. Koch, Michael S. Kallos

Biotechnology and Bioengineering > 121 > 1 > 192 - 205

Equine mesenchymal stromal cells (MSCs) have been found to be beneficial for the treatment of many ailments, including orthopedic injuries, due to their superior differentiation potential and immunomodulating properties. Cell therapies require large cell numbers, which are not efficiently generated using conventional static expansion methods. Expansion of equine cord blood‐derived MSCs (eCB‐MSCs)...

article

Improved expansion of equine cord blood derived mesenchymal stromal cells by using microcarriers in stirred suspension bioreactors

Erin L. Roberts, Tiffany Dang, Sarah I. M. Lepage, Amir Hamed Alizadeh, more

Journal of Biological Engineering > 2019 > 13 > 1 > 1-16

Equine mesenchymal stromal cells (MSCs) are increasingly investigated for their clinical therapeutic utility. Such cell-based treatments can require cell numbers in the millions or billions, with conventional expansion methods using static T-flasks typically inefficient in achieving these cell numbers. Equine cord blood-derived MSCs (eCB-MSCs), are promising cell candidates owing to their capacity...

article

How vertical integration affects the quantity and cost of care for Medicare beneficiaries

Thomas G. Koch, Brett W. Wendling, Nathan E. Wilson

Journal of Health Economics > 2017 > 52 > C > 19-32

Health systems are employing physicians in growing numbers. The implications of this trend are poorly understood and controversial. We use rich data from the Centers for Medicare and Medicaid Services to examine the effects of a set of physician acquisitions by hospital systems on outpatient utilization and spending. We find that financial integration systematically produces economically large changes...

article

Aspiration, but not injection, decreases cultured equine mesenchymal stromal cell viability

Lynn B. Williams, Keith A. Russell, Judith B. Koenig, Thomas G. Koch

BMC Veterinary Research > 2016 > 12 > 1 > 1-7

Background Recently, equine multipotent mesenchymal stromal cells (MSC) have received significant attention as therapy for various conditions due to their proposed regenerative and immune-modulating capacity. MSC are commonly administered to the patient through a hypodermic needle. Currently, little information is available on the effect of such injection has on equine MSC immediate and delayed viability...

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MRI-based relationships between spine pathology, intervertebral disc degeneration, and muscle fatty infiltration in chondrodystrophic and non-chondrodystrophic dogs

Assaf Lerer, Stephanie G. Nykamp, Alexandra B. Harriss, Thomas W.G. Gibson, more

The Spine Journal > 2015 > 15 > 11 > 2433-2439

Human studies have revealed a link between muscle degeneration and low back pain, although the cause and effect of this relationship is not clear. Dogs provide a naturally developing model of intervertebral disc (IVD)-related low back pain that may provide insight into relationships between IVD and muscle degeneration.This study aimed to quantify, via magnetic resonance imaging (MRI), the magnitude...

article

BANKRUPTCY, MEDICAL INSURANCE, AND A LAW WITH UNINTENDED CONSEQUENCES

Thomas G. Koch

Health Economics > 23 > 11 > 1326 - 1339

Congress passed the Emergency Medical Treatment and Active Labor Act (EMTALA) in 1986, guaranteeing a standard of medical care to anyone who entered an emergency room. This guarantee made default a more reliable substitute for medical insurance. I construct a tractable structural model of the medical insurance market and find that repealing EMTALA would increase the fraction of the population with...

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One pool to insure them all? Age, risk and the price(s) of medical insurance

Thomas G. Koch

International Journal of Industrial Organization > 2014 > 35 > Complete > 1-11

Asymmetric information can lead to adverse selection and market failure. In a dynamic setting, asymmetric information also limits reclassification risk. This certainty offsets the costs of adverse selection. Using a dynamic model of endogenous insurance choice and price calibrated to the U.S. medical insurance market, I find that asymmetric information is Pareto improving when information is fully...

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Using RD design to understand heterogeneity in health insurance crowd-out

Thomas G. Koch

Journal of Health Economics > 2013 > 32 > 3 > 599-611

Crowd-out, the switching from private to public insurance, is often found, but estimates are rarely consistent with prior measurements. Cutler and Gruber (1996) found crowd-out in up to half of the newly eligible children, while Card and Shore-Sheppard (2004) found almost none. This paper exploits many regression discontinuity (RD) designs to estimate heterogeneous effects of public insurance eligibility...

article

What Fills the Gaps Left by Employer-Provided Insurance?

Thomas G. Koch

Journal of Labor Research > 2009 > 30 > 4 > 340-349

Employer-provided insurance is the leading source of medical insurance for non-elderly Americans. However, it leaves many without coverage. Evidence suggests that the non-group insurance market does a poor job of filling in these gaps, for those with both short- and long-term uninsurance. It does so for all income and age groups, as well as for both genders. It does fill some of the gaps in employer-provided...

article

Real-time measurement of residence times of gas molecules on solid surfaces

Thomas G. Koch, Frederick F. Fenter, Michel J. Rossi

Chemical Physics Letters > 1997 > 275 > 3-4 > 253-260

A new technique for measuring the surface residence times of gases under molecular flow conditions is described. A pulse of molecules is passed through a cylindrical tube where the molecules undergo multiple collisions with the wall. The transit time, measured using a mass spectrometer, is governed by gas kinetic theory and the magnitude of the gas-surface interaction per collision or surface residence...

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Search results for: Thomas G. Koch

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