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The Trp‐cage, an 18‐20 residue miniprotein, has emerged as a primary test system for evaluating computational fold prediction and folding rate determination efforts. As it turns out, a number of stabilizing interactions in the Trp‐cage folded state have a strong pH dependence; all prior Trp‐cage mutants have been destabilized under carboxylate‐protonating conditions. Notable among the pH dependent...