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Introduction of O2 to Earth's early biosphere stimulated remarkable evolutionary adaptations, and a wide range of electron acceptors allowed diverse, energy‐yielding metabolic pathways. Enzymatic reduction of O2 yielded a several‐fold increase in energy production, enabling evolution of multi‐cellular animal life. However, utilization of O2 also presented major challenges as O2 and many of its derived...
After Fontan operation, patients are limited in increasing cardiac output and in exercise capacity. This has been related to impaired preload or other factors leading to decreased global ventricular performance with stress. To study these factors, the stress responses of functionally univentricular hearts were assessed at rest and during low-dose dobutamine stress using cardiovascular magnetic resonance...
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