Search results for: Carlos M. Villalón

Items from 1 to 20 out of 71 results

article

Streptozotocin‐induced diabetes in rats modifies the role D₂, D₃ and D₄ dopamine receptors play in cardiac sympathetic inhibition

Eduardo Rivera‐Mancilla, Alain H. Altamirano‐Espinoza, Guadalupe Manrique‐Maldonado, Belinda Villanueva‐Castillo, more

Basic & Clinical Pharmacology & Toxicology > 131 > 4 > 262 - 269

Background Diabetes mellitus is associated with abnormalities in peripheral/central catecholaminergic systems, including changes in catecholamine levels and receptor expression. Objective Since quinpirole‐induced cardiac sympathetic inhibition is greater in diabetic than in normoglycemic rats, this study pharmacologically investigated the dopamine D₂‐like receptor subtypes that mediate cardiac...

article

Blockade of 5‐HT₂ receptors with sarpogrelate uncovers 5‐HT₇ receptors inhibiting the tachycardic sympathetic drive in pithed rats

Oswaldo I. Hernández‐Abreu, José Á. García‐Pedraza, Eduardo Rivera‐Mancilla, Belinda Villanueva‐Castillo, more

Clinical and Experimental Pharmacology and Physiology > 47 > 3 > 403 - 411

Our group has previously shown in pithed rats that the cardiac sympathetic drive, which produces tachycardic responses, is inhibited by 5‐HT via the activation of prejunctional 5‐HT_1B/1D/5 receptors. Interestingly, when 5‐HT₂ receptors are chronically blocked with sarpogrelate, the additional role of cardiac sympatho‐inhibitory 5‐HT_1F receptors is unmasked. Although 5‐HT₂ receptors mediate tachycardia...

article

Characterization of binding, functional activity, and contractile responses of the selective 5‐HT_1F receptor agonist lasmiditan

Eloísa Rubio‐Beltrán, Alejandro Labastida‐Ramírez, Kristian A. Haanes, Antoon Bogaerdt, more

British Journal of Pharmacology > 176 > 24 > 4681 - 4695

Background and Purpose Triptans are 5‐HT_1B/1D receptor agonists (that also display 5‐HT_1F receptor affinity) with antimigraine action, contraindicated in patients with coronary artery disease due to their vasoconstrictor properties. Conversely, lasmiditan was developed as an antimigraine 5‐HT_1F receptor agonist. To assess the selectivity and cardiovascular effects of lasmiditan, we investigated the...

article

Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery – potential antimigraine efficacy

Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Kristian A. Haanes, René Vries, more

The Journal of Headache and Pain > 2019 > 20 > 1 > 1-9

Background Racemic isometheptene [(RS)-isometheptene] is an antimigraine drug that due to its cardiovascular side-effects was separated into its enantiomers, (R)- and (S)-isometheptene. This study set out to characterize the contribution of each enantiomer to its vasoactive profile. Moreover, rat neurogenic dural vasodilatation was used to explore their antimigraine mechanism of action. Methods...

article

Differential cardiac sympatho‐inhibitory responses produced by the agonists B‐HT 933, quinpirole and immepip in normoglycaemic and diabetic pithed rats

Eduardo Rivera‐Mancilla, Alain H Altamirano‐Espinoza, Guadalupe Manrique‐Maldonado, Belinda Villanueva‐Castillo, more

Clinical and Experimental Pharmacology and Physiology > 45 > 8 > 767 - 778

This study compared the cardiac sympatho‐inhibitory responses produced by agonists at α₂‐adrenergic (B‐HT 933), dopamine D₂‐like (quinpirole) and histamine H₃/H₄ (immepip) receptors between normoglycaemic and streptozotocin‐pretreated (diabetic) pithed rats. Intravenous (i.v.) continuous infusions of B‐HT 933, quinpirole or immepip were used in normoglycaemic and diabetic pithed rats to analyse their...

article

Characterization of the trigeminovascular actions of several adenosine A_2A receptor antagonists in an in vivo rat model of migraine

Kristian A. Haanes, Alejandro Labastida-Ramírez, Kayi Y. Chan, René de Vries, more

The Journal of Headache and Pain > 2018 > 19 > 1 > 1-10

Background Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels; however, it remains unknown whether adenosine can interact with the trigeminovascular system. Moreover, caffeine, a non-selective adenosine receptor...

article

Dihydroergotamine inhibits the vasodepressor sensory CGRPergic outflow by prejunctional activation of α₂-adrenoceptors and 5-HT₁ receptors

Abimael González-Hernández, Jair Lozano-Cuenca, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink, more

The Journal of Headache and Pain > 2018 > 19 > 1 > 1-10

Background Dihydroergotamine (DHE) is an antimigraine drug that produces cranial vasoconstriction and inhibits trigeminal CGRP release; furthermore, it inhibits the vasodepressor sensory CGRPergic outflow, but the receptors involved remain unknown. Prejunctional activation of α_2A/2C-adrenergic, serotonin 5-HT_1B/1F, or dopamine D₂-like receptors results in inhibition of this CGRPergic outflow. Since...

article

The role of α₁- and α₂-adrenoceptor subtypes in the vasopressor responses induced by dihydroergotamine in ritanserin-pretreated pithed rats

Eduardo Rivera-Mancilla, Victor H. Avilés-Rosas, Guadalupe Manrique-Maldonado, Alain H. Altamirano-Espinoza, more

The Journal of Headache and Pain > 2017 > 18 > 1 > 1-12

Background Dihydroergotamine (DHE) is an acute antimigraine agent that displays affinity for dopamine D₂-like receptors, serotonin 5-HT_1/2 receptors and α₁/α₂-adrenoceptors. Since activation of vascular α₁/α₂-adrenoceptors results in systemic vasopressor responses, the purpose of this study was to investigate the specific role of α₁- and α₂-adrenoceptors mediating DHE-induced vasopressor responses...

article

Pharmacological analysis of the inhibition produced by moxonidine and agmatine on the vasodepressor sensory CGRPergic outflow in pithed rats

Eloísa Rubio-Beltrán, Alejandro Labastida-Ramírez, Oswaldo Hernández-Abreu, Antoinette MaassenVanDenBrink, more

European Journal of Pharmacology > 2017 > 812 > C > 97-103

Calcitonin gene-related peptide (CGRP) plays a role in several (patho)physiological functions, and modulation of its release is considered a therapeutic target. In this respect, electrical spinal (T₉-T₁₂) stimulation of the perivascular sensory outflow in pithed rats produces vasodepressor responses mediated by CGRP release. This study investigated the role of imidazoline I₁ and I₂ receptors in the...

article

Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats

Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Oswaldo Hernández-Abreu, Bruce L. Daugherty, more

The Journal of Headache and Pain > 2017 > 18 > 1 > 1-8

Background Isometheptene is a sympathomimetic drug effective in acute migraine treatment. It is composed of two enantiomers with diverse pharmacological properties. This study investigated in pithed rats the cardiovascular effects of (S)- isometheptene and (R)-isometheptene, and the pharmacological profile of the more potent enantiomer. Methods The effects of i.v. bolus injections (0.03, 0.1, 0...

article

Wiping Out CGRP: Potential Cardiovascular Risks

Antoinette MaassenVanDenBrink, Joris Meijer, Carlos M. Villalón, Michel D. Ferrari

Trends in Pharmacological Sciences > 2016 > 37 > 9 > 779-788

Migraine is a common episodic neurovascular brain disorder associated with increased risk of cardio- and cerebrovascular ischemia. Migraine headache is likely caused by activation of the trigeminovascular system and release of calcitonin gene-related peptide (CGRP). Monoclonal antibodies against CGRP or its receptor are currently being evaluated for the prevention of migraine attacks. Preliminary...

article

Cardiovascular Alterations during the Interictal Period in Awake and Pithed Amygdala‐Kindled Rats

Inna Ruiz‐Salinas, Luisa Rocha, Bruno A. Marichal‐Cancino, Carlos M. Villalón

Basic & Clinical Pharmacology & Toxicology > 119 > 2 > 165 - 172

Epileptic seizures are often accompanied by increased sympathetic cardiovascular activity (even interictally), but it remains unknown whether this increased activity is of central and/or peripheral origin. Hence, this study investigated the cardiovascular alterations produced by amygdala kindling in awake and pithed Wistar rats. Blood pressure (BP) and heart rate (HR) were initially recorded by tail...

article

Role of 5-HT5A and 5-HT1B/1D receptors in the antinociception produced by ergotamine and valerenic acid in the rat formalin test

Guadalupe C. Vidal-Cantú, Mildred Jiménez-Hernández, Héctor I. Rocha-González, Carlos M. Villalón, more

European Journal of Pharmacology > 2016 > 781 > C > 109-116

Sumatriptan, dihydroergotamine and methysergide inhibit 1% formalin-induced nociception by activation of peripheral 5-HT_1B/1D receptors. This study set out to investigate the pharmacological profile of the antinociception produced by intrathecal and intraplantar administration of ergotamine (a 5-HT_1B/1D and 5-HT_5A/5B receptor agonist) and valerenic acid (a partial agonist at 5-HT_5A receptors). Intraplantar...

article

Further evidence for the role of histamine H3, but not H1, H2 or H4, receptors in immepip-induced inhibition of the rat cardioaccelerator sympathetic outflow

Manuel Pinacho-García, Bruno A. Marichal-Cancino, Carlos M. Villalón

European Journal of Pharmacology > 2016 > 773 > C > 85-92

Since histamine H₃ and H₄ receptors are coupled to heterotrimeric G_i/o proteins, a signal transduction pathway associated with inhibition of neurotransmitter release, the present study has investigated the inhibition of the rat cardioaccelerator sympathetic outflow induced by the H₃/H₄ receptor agonist immepip by using antagonists for histamine H₁ (ketotifen), H₂ (ranitidine), H₃ (thioperamide) and...

chapter

Mechanisms of Migraine and Its Treatment

Lars Edvinsson, Antoinette Maassen Brink, Carlos M. Villalón

Handbook of Headache > Migraine > 239-253

Migraine is characterized by recurrent unilateral headaches, accompanied by nausea, vomiting, photophobia, and/or phonophobia, and in some cases facial symptoms. Current theories suggest that the initiation of a migraine attack involves a primary CNS event, putatively involving mutations in ion channels that render the individuals more sensitive to environmental factors, resulting in a wave of cortical...

article

Pharmacological Evidence that Histamine H₃ Receptors Mediate Histamine‐Induced Inhibition of the Vagal Bradycardic Out‐flow in Pithed Rats

Mónica García, José Ángel García‐Pedraza, Carlos M. Villalón, Asunción Morán

Basic & Clinical Pharmacology & Toxicology > 118 > 2 > 113 - 121

In vivo stimulation of cardiac vagal neurons induces bradycardia by acetylcholine (ACh) release. As vagal release of ACh may be modulated by autoreceptors (muscarinic M₂) and heteroreceptors (including serotonin 5‐HT₁), this study has analysed the pharmacological profile of the receptors involved in histamine‐induced inhibition of the vagal bradycardic out‐flow in pithed rats. For this purpose, 180...

article

Specific Role of α_2A‐ and α_2B‐, but not α_2C‐, Adrenoceptor Subtypes in the Inhibition of the Vasopressor Sympathetic Out‐flow in Diabetic Pithed Rats

Alain H. Altamirano‐Espinoza, Guadalupe Manrique‐Maldonado, Bruno A. Marichal‐Cancino, Carlos M. Villalón

Basic & Clinical Pharmacology & Toxicology > 117 > 1 > 31 - 38

Several lines of evidence have shown an association of diabetes with a catecholamines' aberrant homeostasis involving a drastic change in the expression of adrenoceptors. This homeostatic alteration includes, among other things, atypical actions of α₂‐adrenoceptor agonists within central and peripheral α₂‐adrenoceptors (e.g. profound antinociceptive effects in diabetic subjects). Hence, this study...

article

Pharmacological evidence that histamine H3 receptors inhibit the vasodepressor responses by selective stimulation of the rat perivascular sensory CGRPergic outflow

Guadalupe Manrique-Maldonado, Alain H. Altamirano-Espinoza, Bruno A. Marichal-Cancino, Eduardo Rivera-Mancilla, more

European Journal of Pharmacology > 2015 > 754 > Complete > 25-31

This study has investigated whether pharmacological activation of G _i/o coupled histamine H ₃ /H ₄ receptors inhibits the rat vasodepressor sensory outflow. For this purpose, 100 male Wistar rats were pithed, artificially ventilated and pretreated (i.v.) with: 25mg/kg gallamine, 2mg/kg/min hexamethonium and 20μg/kg/min methoxamine, followed by i.v. continuous infusions of physiological...

article

Role of 5-HT7 receptors in the inhibition of the vasodepressor sensory CGRPergic outflow in pithed rats

Cristina Cuesta, José Ángel García-Pedraza, Mónica García, Carlos M. Villalón, more

Vascular Pharmacology > 2014 > 63 > 1 > 4-12

The role of calcitonin gene-related peptide (CGRP) in the modulation of vascular tone has been widely documented. Indeed, electrical stimulation of the perivascular sensory outflow in pithed rats induces vasodepressor responses by activation of CGRP receptors. This study investigated the role of 5-HT ₇ receptors in the inhibition of the rat vasodepressor sensory outflow. Male Wistar pithed...

article

Role of Pre‐Junctional CB₁, But not CB₂, TRPV1 or GPR55 Receptors in Anandamide‐Induced Inhibition of the Vasodepressor Sensory CGRPergic Outflow in Pithed Rats

Bruno A. Marichal‐Cancino, Alain H. Altamirano‐Espinoza, Guadalupe Manrique‐Maldonado, Antoinette MaassenVanDenBrink, more

Basic & Clinical Pharmacology & Toxicology > 114 > 3 > 240 - 247

Stimulation of the perivascular sensory outflow in pithed rats produces vasodepressor responses mediated by CGRP release. Interestingly, endocannabinoids such as anandamide (which interacts with CB₁, CB₂, TRPV1 and GPR55 receptors) can regulate the activity of perivascular sensory nerves in dural blood vessels by modulating CGRP release. Yet, as no publication has reported whether this mechanism is...

Publication date

Last 3 years (1)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

INFONA - science communication portal

Search results for: Carlos M. Villalón

Streptozotocin‐induced diabetes in rats modifies the role D₂, D₃ and D₄ dopamine receptors play in cardiac sympathetic inhibition

Blockade of 5‐HT₂ receptors with sarpogrelate uncovers 5‐HT₇ receptors inhibiting the tachycardic sympathetic drive in pithed rats

Characterization of binding, functional activity, and contractile responses of the selective 5‐HT_1F receptor agonist lasmiditan

Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery – potential antimigraine efficacy

Differential cardiac sympatho‐inhibitory responses produced by the agonists B‐HT 933, quinpirole and immepip in normoglycaemic and diabetic pithed rats

Characterization of the trigeminovascular actions of several adenosine A_2A receptor antagonists in an in vivo rat model of migraine

Dihydroergotamine inhibits the vasodepressor sensory CGRPergic outflow by prejunctional activation of α₂-adrenoceptors and 5-HT₁ receptors

The role of α₁- and α₂-adrenoceptor subtypes in the vasopressor responses induced by dihydroergotamine in ritanserin-pretreated pithed rats

Pharmacological analysis of the inhibition produced by moxonidine and agmatine on the vasodepressor sensory CGRPergic outflow in pithed rats

Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats

Wiping Out CGRP: Potential Cardiovascular Risks

Cardiovascular Alterations during the Interictal Period in Awake and Pithed Amygdala‐Kindled Rats

Role of 5-HT5A and 5-HT1B/1D receptors in the antinociception produced by ergotamine and valerenic acid in the rat formalin test

Further evidence for the role of histamine H3, but not H1, H2 or H4, receptors in immepip-induced inhibition of the rat cardioaccelerator sympathetic outflow

Mechanisms of Migraine and Its Treatment

Pharmacological Evidence that Histamine H₃ Receptors Mediate Histamine‐Induced Inhibition of the Vagal Bradycardic Out‐flow in Pithed Rats

Specific Role of α_2A‐ and α_2B‐, but not α_2C‐, Adrenoceptor Subtypes in the Inhibition of the Vasopressor Sympathetic Out‐flow in Diabetic Pithed Rats

Pharmacological evidence that histamine H3 receptors inhibit the vasodepressor responses by selective stimulation of the rat perivascular sensory CGRPergic outflow

Role of 5-HT7 receptors in the inhibition of the vasodepressor sensory CGRPergic outflow in pithed rats

Role of Pre‐Junctional CB₁, But not CB₂, TRPV1 or GPR55 Receptors in Anandamide‐Induced Inhibition of the Vasodepressor Sensory CGRPergic Outflow in Pithed Rats

Filter options

Publication date

Content availability

Publication type

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Carlos M. Villalón

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options