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Two photo‐crosslinking biarsenical (CrAsH‐EDT2)‐modified probes were synthesized that are expected to be useful tools for tetracysteine‐labeled proteins to facilitate the co‐affinity purification of their DNA binding sequences and interacting proteins. In addition, improvements for the synthesis of CrAsH‐EDT2 and N1‐(4‐azido‐2‐nitrophenyl)hexane‐1,6‐diamine are reported. Both photoprobes effectively...
The balance of evidence from numerous studies on psychiatric diseases and disorders suggests that for (at the least) schizophrenia, bipolar disorder, autism and unipolar depression, a significant component of these disorders can be linked to a genetic component. This article will give a broad overview of the influence of genetics on psychiatric disease, and attempt to bring in recent molecular approaches...
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