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BackgroundBaclofen, a GABAB agonist, has been shown to reduce transient lower oesophageal sphincter relaxations (TLESRs), a major cause of gastro‐oesophageal reflux disease (GERD).
AimTo examine the effect and tolerability of baclofen in GERD patients over a 2‐week period.
MethodsForty‐three GERD patients with abnormal 24‐h pH tests were prospectively randomised to receive baclofen or placebo in...