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AimCalpain activation has a putative role in ischaemia‐reperfusion injury of cardiomyocytes. This study clarified the in vivo contribution of calpain to disruption of cardiomyocyte sarcolemma during ischaemia and after reperfusion in anaesthetized rats.
MethodsUsing a microdialysis technique in the hearts of anaesthetized rats, we investigated the effects of the calpain inhibitors on myocardial interstitial...
AimAlthough deleterious effects of serotonin (5‐HT) have been demonstrated during myocardial ischaemia‐reperfusion, little information is available on myocardial interstitial 5‐HT kinetics. This study evaluated the contribution of 5‐HT reuptake and degradation to myocardial interstitial 5‐HT levels during ischaemia‐reperfusion.
MethodsUsing microdialysis technique in anaesthetized rabbits, we monitored...
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