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Sauerstoffheterocyclen sind verbreitete Strukturmotive in Polyketid‐Naturstoffen. Wir berichten über strukturelle und mechanistische Untersuchungen zu AmbDH3, einer Polyketidsynthase‐Domäne mit dualer Aktivität als Dehydratase (DH) und pyranbildende Cyclase in der Ambruticin‐Biosynthese. AmbDH3 ähnelt monofunktionalen DH‐Domänen und verwendet H51 und D215 zur Dehydratisierung. Durch Mutationsstudien...
Oxygen‐containing heterocycles are a common structural motif in polyketide natural products and contribute significantly to their biological activity. Here, we report structural and mechanistic investigations on AmbDH3, a polyketide synthase domain with dual activity as dehydratase (DH) and pyran‐forming cyclase in ambruticin biosynthesis. AmbDH3 is similar to monofunctional DH domains, using H51...
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