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Although octamer‐binding transcription factor 4 (Oct‐4) is one of the most intensively studied factors in mammalian development, no cellular genes capable of replacing Oct‐4 function in embryonic stem (ES) cells have been found. Recent data show that nuclear receptor subfamily 5, group A, member 2 (Nr5a2) is able to replace Oct‐4 function in the reprogramming process; however, it is unclear whether...
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