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Background
To assess the utility of Magnetic Resonance Spectroscopy (MRS) as a biomarker of response to L‐arginine in mitochondrial encephalomyopathy with lactic acidosis and stroke‐like episodes (MELAS).
Aims
To describe a case of MELAS treated with L‐arginine that showed improvement clinically and on serial MRS
Methods
MRS was performed on a 1.5‐Tesla scanner to evaluate a MELAS patient before,...
Targeted therapy for metastatic diseases relies on the identification of functionally important metastasis genes from a large number of random genetic alterations. Here we use a computational algorithm to map minimal recurrent genomic alterations associated with poor-prognosis breast cancer. 8q22 genomic gain was identified by this approach and validated in an extensive collection of breast tumor...
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