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Induction of endothelial cytotoxicity by hyperglycemia in diabetes has been widely accepted. Emodin is a natural anthraquinone in rhubarb used for treatment of diabetes, but its mechanism of action is not fully understood. This study aimed to examine the potential beneficial effects of emodin on endothelial cytotoxicity caused by high glucose milieu. Culture of human umbilical vein endothelial cells...
Osthole is used as antiproliferation, vasorelaxation, antihepatitis, anti-inflammatory, antiaggregatory, and antiallergic effects in traditional medicine. Recently, osthole has been shown to ameliorate insulin resistance and decrease the fasting blood glucose (FBG) in high-sucrose and high-fat induced fatty liver rats. However the mechanism of its anti-diabetes is not very understood. In this work...
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