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Endothelial dysfunction is the central pathophysiologic denominator for all microvascular complications of diabetes, including nephropathy. Abnormalities of endothelin-1 and nitric oxide (NO) modulate renal structure and function in diabetes. We study the role of endothelin-1 and NO in the diabetic kidney. This study includes a total of 60 type-2 diabetic patients and 20 healthy subjects as a control...